2013 Fiscal Year Final Research Report
Identification of RPS6KA1 as novel molecular target of rhabdomyosarcoma
| Project/Area Number |
24791078
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pediatrics
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
MIYACHI Mitsuru 京都府立医科大学, 医学(系)研究科(研究院), 助教 (40584983)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | RPS6KA1 / 横紋筋肉腫 / 分子標的療法 |
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| Research Abstract |
We compared the expression pattern of mouse myoblasts which express rhabdomyosarcoma-specific fusion gene and identified the candidate gene as Rps6ka1. We examined rhabdomyosarcoma tumor specimens and found that RPS6KA1 is overexpressed compared with normal human skeletal muscle. RPS6KA1 inhibitor, BI-D1870, inhibited the proliferation of rhabdomyosarcoma cells and G2/M cell cycle arrest was observed. BI-D1870 treatment induced Myosin Heavy Chain expression and differentiation of rhabdomyosarcoma cells. RPS6KA1 may be a novel therapeutic target of rhabdomyosarcoma.
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