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Elucidation of mechanism of pathogenesis of IgA nephropathy forcusing on the mesangial IgA receptors

Research Project

Project/Area Number 24791082
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Pediatrics
Research InstitutionWakayama Medical University

Principal Investigator

SHIMA Yuko  和歌山県立医科大学, 医学部, 助教 (60433364)

Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords小児IgA腎症 / IgA受容体 / FcαR / メサンギウムIgA沈着 / Fcα/μR / IgA腎症 / Fcα受容体 / Fcα/μ受容体
Outline of Final Research Achievements

IgA nephropathy (IgAN) is most common primary chronic glomerulonephritis in the world. Although the pathogenesis of IgAN remains uncertain, immunological abnormalities that leads to the formation of IgA immune complex and mesangial deposition of IgA may play a crucial role of the pathogenesis of IgAN. We reported that some of the patients with IgAN show the disappearance of glomerular IgA deposits after treatments and that the IgAN patients with IgA disappearance showed better renal survival than the IgAN patients without IgA disappearance. So the relationship between the factors of mesangial IgA deposition and the progression of inflammation is important.
And we analyzed the relationship between the degree of expression of IgA receptors and mesangial proliferation. In the study of mesangial IgA receptors expression in renal biopsy specimens of the patients with IgAN, the expression of FcαR showed significant correlation with the degree of mesangial proliferation.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (17 results)

All 2015 2014 2013 2012

All Journal Article (9 results) (of which Peer Reviewed: 9 results,  Open Access: 1 results) Presentation (6 results) Book (2 results)

  • [Journal Article] Biopsy timing and Oxford classification variables in childhood/adolescent IgA nephropathy.2015

    • Author(s)
      Shima Y, Nakanishi K, Hama T, Sato M, Mukaiyama H, Togawa H, Tanaka R, Kaito H, Nozu K, Iijima K, Yoshikawa N.
    • Journal Title

      Pediatric Nephrollogy

      Volume: 30(2) Issue: 2 Pages: 293-9

    • DOI

      10.1007/s00467-014-2862-z

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Renal biopsy criterion in idiopathic nephrotic syndrome with microscopic hematuria at onset2015

    • Author(s)
      Hama T, Nakanishi K, Shima Y, Sato M, Mukaiyama H, Togawa H, Hamahira K, Tanaka R, Kaito H, Nozu K, Iijima K, Yoshikawa N
    • Journal Title

      Pediatr Nephrol

      Volume: 30 Issue: 3 Pages: 445-450

    • DOI

      10.1007/s00467-014-2946-9

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A multicenter randomized trial indicates initial prednisolone treatment for childhood nephrotic syndrome for two months is not inferior to six-month treatment2015

    • Author(s)
      Yoshikawa N, Nakanishi K, Sako M, Oba MS, Mori R, Ota E, Ishikura K, Hataya H, Honda M, Ito S, Shima Y, Kaito H, Nozu K, Nakamura H, Igarashi T, Ohashi Y, Iijima K
    • Journal Title

      Kidney Int

      Volume: 87 Issue: 1 Pages: 225-232

    • DOI

      10.1038/ki.2014.260

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Endoplasmic reticulum stress with low-dose cyclosporine in frequently relapsing nephrotic syndrome2013

    • Author(s)
      Hama T, Yoshikawa N, et al
    • Journal Title

      Pediatr Nephrol

      Volume: 28 Issue: 6 Pages: 903-909

    • DOI

      10.1007/s00467-012-2403-6

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] First Japanese case of Pierson syndrome with mutations in LAMB22013

    • Author(s)
      Togawa H, Yoshikawa N, et al
    • Journal Title

      Pediatr Int

      Volume: 55 Issue: 2 Pages: 229-231

    • DOI

      10.1111/j.1442-200x.2012.03629.x

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Molecular background of urate transporter geneMolecular background of urate transporter genes in patients with exercise-induced acute kidney injury.2013

    • Author(s)
      Kaito H, Ishimori Kaito H, Ishimori S, Nozu K, Shima Y, Nakanishi K, Yoshikawa N, Iijima K.
    • Journal Title

      Am J Nephrol.

      Volume: 38(4) Issue: 4 Pages: 629-629

    • DOI

      10.1159/000355430

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Spontaneous remission in children with IgA nephropathy2013

    • Author(s)
      Shima Y, Yoshikawa N, et al
    • Journal Title

      Pediatr Nephrol

      Volume: 28 Issue: 1 Pages: 71-76

    • DOI

      10.1007/s00467-012-2294-6

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Validity of the Oxford classification of IgA nephropathy in children.2012

    • Author(s)
      Shima Y, Nakanishi K, Hama T, Mukaiyama H, Togawa H, Hashimura Y, Kaito H, Sako M, Iijima K, Yoshikawa N
    • Journal Title

      Pediatr Nephrol.

      Volume: 27(5) Issue: 5 Pages: 783-92

    • DOI

      10.1007/s00467-011-2061-0

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Renal biopsy criterion in children with asymptomatic constant isolated proteinuria.2012

    • Author(s)
      Hama T, Nakanishi K, Shima Y, Mukaiyama H, Togawa H, Tanaka R, Hamahira K, Kaito H, Iijima K, Yoshikawa N
    • Journal Title

      Nephrol Dial Transplant.

      Volume: 27(8) Issue: 8 Pages: 3186-90

    • DOI

      10.1093/ndt/gfr750

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] IgA腎症におけるNLRP3の役割の解析2014

    • Author(s)
      島友子、中西浩一、濱武継、向山弘展、佐藤匡、戸川寛子、吉川徳茂
    • Organizer
      第57回日本腎臓学会学術集会
    • Place of Presentation
      パシフィコ横浜 会議センター
    • Year and Date
      2014-07-04 – 2014-07-06
    • Related Report
      2014 Annual Research Report
  • [Presentation] The relationship between timing of renal biopsy and pathological variables of the Oxford classification in childhood IgA Nephropathy2013

    • Author(s)
      Shima Y, Nakanishi K, Mukaiyama H, Hama T, Togawa H, Tanaka R, Iijima K, Yoshikawa N
    • Organizer
      The 16th congress of the International Pediatric Nephrology Association
    • Place of Presentation
      Shanghai, China
    • Related Report
      2013 Research-status Report
  • [Presentation] Crescentic IgA Nephropathy in children2013

    • Author(s)
      Shima Y, Nakanishi K, Hama T, Mukaiyama H, Togawa H, Sato M, Nozu K, Tanaka R, Iijima K, Yoshikawa N
    • Organizer
      American Society of Nephrology
    • Place of Presentation
      Atlanta, USA
    • Related Report
      2013 Research-status Report
  • [Presentation] 半月体形成性糸球体腎炎を呈する小児IgA腎症について2013

    • Author(s)
      島友子、中西浩一、向山弘展、浜武継、田中亮二郎、飯島一誠、吉川徳茂
    • Organizer
      第48回日本小児腎臓病学会学術集会
    • Place of Presentation
      徳島
    • Related Report
      2013 Research-status Report
  • [Presentation] Histological predictors of treatment efficacy in severe childhood IgA nephropathy (IgAN): validation of the Oxford classification of IgAN (Ox C)2012

    • Author(s)
      Shima Y, Nakanishi K, Hama T, Mukaiyama H, Togawa H,Ishimori S, Kaito H, Tanaka R, Iijima K, Yoshikawa N
    • Organizer
      45th Annual Meeting of the American Society of Nephrology
    • Place of Presentation
      San Diego, USA
    • Related Report
      2012 Research-status Report
  • [Presentation] 小児IgA腎症におけるOxford分類腎病理因子と腎生検時期の検討2012

    • Author(s)
      島友子、中西浩一、向山弘展、濱武継、田中亮二郎、飯島一誠、吉川徳茂
    • Organizer
      第47回日本小児腎臓病学会学術集会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
  • [Book] 特集 負荷試験の実際 2013 ピラジナマイド抑制試験、プロべネシド試験2013

    • Author(s)
      島友子、中西浩一、吉川徳茂
    • Total Pages
      267
    • Publisher
      東京医学社
    • Related Report
      2013 Research-status Report
  • [Book] 小児の臨床手技100  腎生検2012

    • Author(s)
      島友子、中西浩一、吉川徳茂
    • Total Pages
      474
    • Publisher
      診断と治療社
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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