Elucidation of mechanism of pathogenesis of IgA nephropathy forcusing on the mesangial IgA receptors

• Project/Area Number: 24791082
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Pediatrics
• Research Institution: Wakayama Medical University
• Principal Investigator: SHIMA Yuko 和歌山県立医科大学, 医学部, 助教 (60433364)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 小児IgA腎症 / IgA受容体 / FcαR / メサンギウムＩｇＡ沈着 / Fcα/μR / IgA腎症 / Fcα受容体 / Fｃα/μ受容体

Outline of Final Research Achievements

IgA nephropathy (IgAN) is most common primary chronic glomerulonephritis in the world. Although the pathogenesis of IgAN remains uncertain, immunological abnormalities that leads to the formation of IgA immune complex and mesangial deposition of IgA may play a crucial role of the pathogenesis of IgAN. We reported that some of the patients with IgAN show the disappearance of glomerular IgA deposits after treatments and that the IgAN patients with IgA disappearance showed better renal survival than the IgAN patients without IgA disappearance. So the relationship between the factors of mesangial IgA deposition and the progression of inflammation is important.
And we analyzed the relationship between the degree of expression of IgA receptors and mesangial proliferation. In the study of mesangial IgA receptors expression in renal biopsy specimens of the patients with IgAN, the expression of FcαR showed significant correlation with the degree of mesangial proliferation.

Research Products

• [Journal Article] Biopsy timing and Oxford classification variables in childhood/adolescent IgA nephropathy. (2015)
  • Author(s): Shima Y, Nakanishi K, Hama T, Sato M, Mukaiyama H, Togawa H, Tanaka R, Kaito H, Nozu K, Iijima K, Yoshikawa N.
  • Journal Title: Pediatric Nephrollogy Volume: 30(2) Issue: 2 Pages: 293-9
  • DOI: 10.1007/s00467-014-2862-z
  • Peer Reviewed
• [Journal Article] Renal biopsy criterion in idiopathic nephrotic syndrome with microscopic hematuria at onset (2015)
  • Author(s): Hama T, Nakanishi K, Shima Y, Sato M, Mukaiyama H, Togawa H, Hamahira K, Tanaka R, Kaito H, Nozu K, Iijima K, Yoshikawa N
  • Journal Title: Pediatr Nephrol Volume: 30 Issue: 3 Pages: 445-450
  • DOI: 10.1007/s00467-014-2946-9
  • Peer Reviewed
• [Journal Article] A multicenter randomized trial indicates initial prednisolone treatment for childhood nephrotic syndrome for two months is not inferior to six-month treatment (2015)
  • Author(s): Yoshikawa N, Nakanishi K, Sako M, Oba MS, Mori R, Ota E, Ishikura K, Hataya H, Honda M, Ito S, Shima Y, Kaito H, Nozu K, Nakamura H, Igarashi T, Ohashi Y, Iijima K
  • Journal Title: Kidney Int Volume: 87 Issue: 1 Pages: 225-232
  • DOI: 10.1038/ki.2014.260
  • Peer Reviewed / Open Access
• [Journal Article] Endoplasmic reticulum stress with low-dose cyclosporine in frequently relapsing nephrotic syndrome (2013)
  • Author(s): Hama T, Yoshikawa N, et al
  • Journal Title: Pediatr Nephrol Volume: 28 Issue: 6 Pages: 903-909
  • DOI: 10.1007/s00467-012-2403-6
  • Peer Reviewed
• [Journal Article] First Japanese case of Pierson syndrome with mutations in LAMB2 (2013)
  • Author(s): Togawa H, Yoshikawa N, et al
  • Journal Title: Pediatr Int Volume: 55 Issue: 2 Pages: 229-231
  • DOI: 10.1111/j.1442-200x.2012.03629.x
  • Peer Reviewed
• [Journal Article] Molecular background of urate transporter geneMolecular background of urate transporter genes in patients with exercise-induced acute kidney injury. (2013)
  • Author(s): Kaito H, Ishimori Kaito H, Ishimori S, Nozu K, Shima Y, Nakanishi K, Yoshikawa N, Iijima K.
  • Journal Title: Am J Nephrol. Volume: 38(4) Issue: 4 Pages: 629-629
  • DOI: 10.1159/000355430
  • Peer Reviewed
• [Journal Article] Spontaneous remission in children with IgA nephropathy (2013)
  • Author(s): Shima Y, Yoshikawa N, et al
  • Journal Title: Pediatr Nephrol Volume: 28 Issue: 1 Pages: 71-76
  • DOI: 10.1007/s00467-012-2294-6
  • Peer Reviewed
• [Journal Article] Validity of the Oxford classification of IgA nephropathy in children. (2012)
  • Author(s): Shima Y, Nakanishi K, Hama T, Mukaiyama H, Togawa H, Hashimura Y, Kaito H, Sako M, Iijima K, Yoshikawa N
  • Journal Title: Pediatr Nephrol. Volume: 27(5) Issue: 5 Pages: 783-92
  • DOI: 10.1007/s00467-011-2061-0
  • Peer Reviewed
• [Journal Article] Renal biopsy criterion in children with asymptomatic constant isolated proteinuria. (2012)
  • Author(s): Hama T, Nakanishi K, Shima Y, Mukaiyama H, Togawa H, Tanaka R, Hamahira K, Kaito H, Iijima K, Yoshikawa N
  • Journal Title: Nephrol Dial Transplant. Volume: 27(8) Issue: 8 Pages: 3186-90
  • DOI: 10.1093/ndt/gfr750
  • Peer Reviewed
• [Presentation] IgA腎症におけるNLRP3の役割の解析 (2014)
  • Author(s): 島友子、中西浩一、濱武継、向山弘展、佐藤匡、戸川寛子、吉川徳茂
  • Organizer: 第57回日本腎臓学会学術集会
  • Place of Presentation: パシフィコ横浜 会議センター
  • Year and Date: 2014-07-04 – 2014-07-06
• [Presentation] The relationship between timing of renal biopsy and pathological variables of the Oxford classification in childhood IgA Nephropathy (2013)
  • Author(s): Shima Y, Nakanishi K, Mukaiyama H, Hama T, Togawa H, Tanaka R, Iijima K, Yoshikawa N
  • Organizer: The 16th congress of the International Pediatric Nephrology Association
  • Place of Presentation: Shanghai, China
• [Presentation] Crescentic IgA Nephropathy in children (2013)
  • Author(s): Shima Y, Nakanishi K, Hama T, Mukaiyama H, Togawa H, Sato M, Nozu K, Tanaka R, Iijima K, Yoshikawa N
  • Organizer: American Society of Nephrology
  • Place of Presentation: Atlanta, USA
• [Presentation] 半月体形成性糸球体腎炎を呈する小児IgA腎症について (2013)
  • Author(s): 島友子、中西浩一、向山弘展、浜武継、田中亮二郎、飯島一誠、吉川徳茂
  • Organizer: 第48回日本小児腎臓病学会学術集会
  • Place of Presentation: 徳島
• [Presentation] Histological predictors of treatment efficacy in severe childhood IgA nephropathy (IgAN): validation of the Oxford classification of IgAN (Ox C) (2012)
  • Author(s): Shima Y, Nakanishi K, Hama T, Mukaiyama H, Togawa H,Ishimori S, Kaito H, Tanaka R, Iijima K, Yoshikawa N
  • Organizer: 45th Annual Meeting of the American Society of Nephrology
  • Place of Presentation: San Diego, USA
• [Presentation] 小児IgA腎症におけるOxford分類腎病理因子と腎生検時期の検討 (2012)
  • Author(s): 島友子、中西浩一、向山弘展、濱武継、田中亮二郎、飯島一誠、吉川徳茂
  • Organizer: 第47回日本小児腎臓病学会学術集会
  • Place of Presentation: 東京
• [Book] 特集 負荷試験の実際 2013 ピラジナマイド抑制試験、プロべネシド試験 (2013)
  • Author(s): 島友子、中西浩一、吉川徳茂
  • Total Pages: 267
  • Publisher: 東京医学社
• [Book] 小児の臨床手技100 腎生検 (2012)
  • Author(s): 島友子、中西浩一、吉川徳茂
  • Total Pages: 474
  • Publisher: 診断と治療社