Therapeutic strategy of phenylketonuria fetal model mouse using self-complementary adeno-associated virus vector
| Project/Area Number |
24791106
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Embryonic/Neonatal medicine
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| Research Institution | University of Tsukuba |
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Principal Investigator |
YAGI HIROYA 筑波大学, 医学医療系, 講師 (70625623)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | AAVベクター / 胎児遺伝子治療 / 遺伝子治療 / 国際情報交換 |
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| Outline of Final Research Achievements |
It was intended to be introduced and expressed gene long-term immune tolerance a small amount vector by infecting an AAV vector treating Phenylketoruria into fetuses in utero. To examine the most susceptible serotype of the AAV vector, 2, 5, 6 type AAV were made and examined the infectivity of the placental epithelium. Although HPIEpC cells were used and infected with various AAV vectors per cell 10∧6vector particle, expression was not observed any serotype.
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Report
(4 results)
Research Products
(4 results)
