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The role of mast cells on host defense against lethal herpes simplex virus infection

Research Project

Project/Area Number 24791144
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Dermatology
Research InstitutionUniversity of Yamanashi

Principal Investigator

AOKI Rui  山梨大学, 医学部附属病院, 助教 (10377541)

Research Collaborator KAWAMURA Tatsuyoshi  山梨大学, 医学部附属病院, 講師 (70262657)
SHIMADA Shinji  山梨大学, 医学工学総合研究部, 教授 (10114505)
Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Keywordsマスト細胞 / 単純ヘルペスウイルス / 自然免疫 / HSV
Research Abstract

Mast cells are known as important players in innate immune responses. The essential contribution of mast cells to bacterial host defense has been well established; however, little is known about their role in viral infections. We have reported that mast cells were critically involved in host defense at herpes simplex virus 2 (HSV-2)-infected sites through TNF-a and IL-6 production. HSV did not directly induce TNF-a or IL-6 production by mast cells, whereas supernatants from HSV-infected keratinocytes induced production of these cytokines by mast cells. Therefore, we examined which factor derived from HSV-infected keratinocytes activated mast cells. We found that IL-33, known as an alarmin in innate immune responses, was elevated in HSV-infected skin and triggered TNF-a and IL-6 production by mast cells.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (12 results)

All 2013 2012

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (7 results)

  • [Journal Article] Mast cells play a key role in host defense against herpes simplex virus infection through TNF-α and IL-6 production2013

    • Author(s)
      Aoki R, Kawamura T, Goshima F, Ogawa Y, Nakae S, Nakao A, Moriishi K, Nishiyama Y, Shimada S
    • Journal Title

      J Invest Dermatol

      Volume: 133(9) Issue: 9 Pages: 2170-9

    • DOI

      10.1038/jid.2013.150

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Oral administration of the CCR5 inhibitor , maraviroc, blocks HIV ex vivo infection of Langerhans cells within the epithelium2013

    • Author(s)
      Matsuzawa T, Kawamura T, Ogawa Y, Takahashi M, Aoki R, Moriishi K, Koyanagi Y, Gatanaga H, Blauvelt A, Shimada S
    • Journal Title

      J Invest Dermatol

      Volume: 133(12) Issue: 12 Pages: 2803-5

    • DOI

      10.1038/jid.2013.215

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Antimicrobial peptide LL-37 produced by HSV-2-infected keratinocytes enhances HIV infection of Langerhans cells2013

    • Author(s)
      Ogawa Y, Kawamura T, Matsuzawa T, Aoki R, Gee P, Yamashita A, Moriishi K, Yamasaki K, Koyanagi Y. Blauvelt A, Shimada S.
    • Journal Title

      Cell Host and Microbe

      Volume: 13 Issue: 1 Pages: 77-86

    • DOI

      10.1016/j.chom.2012.12.002

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mast Cells Play a Key Role in Host Defense against Herpes Simplex Virus Infection through TNF-α and IL-6 Production.2013

    • Author(s)
      Aoki R, Kawamura T, Goshima F, Ogawa Y, Nakae S, Nakao A, Moriishi K, Nishiyama Y, Shimada S.
    • Journal Title

      J Invest Dermatol.

      Volume: 133(9) Pages: 2170-2179

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mast cells play a key role in host defense against herpes simplex virus infection through TNF-α and IL-6 production2013

    • Author(s)
      Rui Aoki
    • Journal Title

      Journal of investigative dermatology

      Volume: 133

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] The alarmin IL-33 derived from HSV-2-infected keratinocytes triggers mast cell-mediated antiviral innate immunity2013

    • Author(s)
      青木 類
    • Organizer
      International Investigative Dermatology
    • Place of Presentation
      Edinburgh (Scotland)
    • Year and Date
      2013-05-10
    • Related Report
      2013 Final Research Report
  • [Presentation] The alarmin IL- 33 derived from HSV- 2- infected keratinocytes triggers mast cell- mediated antiviral innate immunity2013

    • Author(s)
      Rui Aoki
    • Organizer
      International Investigative Dermatology
    • Place of Presentation
      Edinburgh International Conference Centre (Edinburgh, Scotland)
    • Related Report
      2013 Annual Research Report
  • [Presentation] The alarmin IL-33 derived from HSV-2-infected keratinocytes triggers mast cell-mediated antiviral innate immunity2013

    • Author(s)
      Rui Aoki
    • Organizer
      International Investigative Dermatology
    • Place of Presentation
      Edinburgh International Conference Centre (Edinburgh, Scotland)
    • Related Report
      2012 Research-status Report
  • [Presentation] IL-33 triggers mast cell-mediated innate immunity against lethal herpes simplex virus infection through TNF-α and IL-62012

    • Author(s)
      青木 類
    • Organizer
      The 37th Annual Meeting of Japanese Society for Investigative Dermatology
    • Place of Presentation
      沖縄
    • Year and Date
      2012-12-08
    • Related Report
      2013 Final Research Report
  • [Presentation] IL-33 triggers mast cell-mediated innate immunity against lethal herpes simplex virus infection through TNF-α and IL-62012

    • Author(s)
      青木 類
    • Organizer
      The 42th Annual European Society for Dermatological Research meeting
    • Place of Presentation
      Venice(Italy)
    • Year and Date
      2012-09-21
    • Related Report
      2013 Final Research Report
  • [Presentation] IL-33 triggers mast cell-mediated innate immunity against lethal herpes simplex virus infection through TNF-α and IL-62012

    • Author(s)
      Rui Aoki
    • Organizer
      European Society for Dermatological Research
    • Place of Presentation
      Plazzo del Casino, Venice Lido Congress Centre (Venice, Italy)
    • Related Report
      2012 Research-status Report
  • [Presentation] IL-33 triggers mast cell-mediated innate immunity against lethal herpes simplex virus infection through TNF-α and IL-62012

    • Author(s)
      Rui Aoki
    • Organizer
      Japanese Society for Investigative Dermatology
    • Place of Presentation
      Loisir Hotel & Spa Tower (那覇、沖縄)
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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