| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Research Abstract |
We investigated the gene profile of the inflammation molecules with DNA array in the psoriasis skin and found that SAA is the one of the molecule higher expressed. The SAA is one of the apolipoprotein family, mainly present in the plasma.SAA is known to be elevated at the time of malignancy,fungal infections, viral infections, and Rheumatoid Arthritis. Sometimes, SAA is used to identify the disease activity as a sensitive marker than CRP. We evaluated that IL-6 and 23 production were significantly increased, especially MoLCs, in response to SAA in vitro. Moreover, we isolated human naive CD4+ T cells from PBMCs and were co-cultured with MoDCs/MoLCs in SAA stimulated condition, we assessed Th17 cell differentiation in a SAA dose dependent manner.These results indicate that SAA expressed in the psoriatic skin lesion induces TH 17 differentiation through IL-6 and 23 signaling, which leads to establish and maintain the psoriatic skin lesions.
|
