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Role as a prognotic factor of Pict-1 in Skin carcinogenesis

Research Project

Project/Area Number 24791173
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Dermatology
Research InstitutionJichi Medical University

Principal Investigator

NARITA Tae  自治医科大学, 医学部, 研究員 (10301061)

Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
KeywordsPTEN / Pict-1 / p53 / 日光角化症 / 有棘細胞癌 / PICT1 / 癌抑制遺伝子 / PICT-1 / 角化細胞 / 皮膚発癌 / 皮膚癌 / 紫外線発癌
Outline of Final Research Achievements

Pict-1 stabilizes PTEN, regulates the MDM2-p53 pathway. High expression levels of Pict1 are associated poor prognosis of several cancers with wild-type TP53. Solar Keratosis develops squamous cell carcinoma(SCC) in skin, so we studied clinical prognosis of solar keratosis in human with topical imiquimod application. Some clinical parameters, e.g. solitary, multiple, CR, PD, SCC progression were investigated. Immunohistochemical expression of Pict-1 and p53(WT, mutant) revealed imiquimod effective solar keratosis(CR) with higher cytoplasmic and nuclear Pict-1. It decreases imiquimod resistant solar keratosis(PD) and SCC. Weak p53 expression with strong cytoplasmic Pict1 in CR case, and no p53 expression in PD case. Paradoxically, strong p53 expression of SCC, suggesting more mutant p53 in SCC. These result suggests some mechanisms of UV carcinogenesis prevention in epidermis might regulate Pict-1 and p53 expression.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (13 results)

All 2015 2014 2013 2012 Other

All Journal Article (4 results) (of which Peer Reviewed: 2 results) Presentation (6 results) Book (2 results) Remarks (1 results)

  • [Journal Article] 尋常性乾癬のアダリムマブ投与中に生じた逆説的反応2015

    • Author(s)
      成田多恵、塚原理恵子、出光俊郎
    • Journal Title

      皮膚病診療

      Volume: 36 Pages: 413-416

    • Related Report
      2014 Annual Research Report 2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Your Diagnosis, 限局性全身性強皮症(limited cutaneous SSc: IcSSc)2015

    • Author(s)
      井上多恵、出光俊郎
    • Journal Title

      Visual Dermatology

      Volume: 14 Pages: 606-608

    • Related Report
      2014 Annual Research Report
  • [Journal Article] 膿疱をみたとき2014

    • Author(s)
      成田多恵、出光俊郎
    • Journal Title

      J Visual Dermatol

      Volume: 13 Pages: 434-437

    • Related Report
      2013 Research-status Report
  • [Journal Article] 【体幹の皮膚病-非炎症性】 <臨床例>融合性細網状乳頭腫症2013

    • Author(s)
      塚原理恵子、出光俊郎、成田多恵
    • Journal Title

      皮膚病診療

      Volume: 35 Pages: 537-540

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] 日光角化症に対するイミキモド5%クリーム(ベセルナクリームR)使用の予後に関する検討2014

    • Author(s)
      成田多恵
    • Organizer
      Saitama ベセルナクリーム研究会
    • Place of Presentation
      さいたま
    • Year and Date
      2014-07-17
    • Related Report
      2014 Annual Research Report
  • [Presentation] 疱性類天疱瘡の治療中に腸穿孔を来した1例およびカリニ肺炎で死亡した2例.2012

    • Author(s)
      小山尚俊、飯田絵理、塚原絵里子、中村考伸、成田多恵、正木真澄、加倉井真樹、梅本尚可、山田朋子、出光俊郎
    • Organizer
      第34回水疱症研究会
    • Place of Presentation
      青森県弘前市
    • Related Report
      2012 Research-status Report
  • [Presentation] 難治性水疱性類天疱瘡に対してステロイドパルス療法、IVIG, DFPPを行い軽快した1例.2012

    • Author(s)
      小山尚俊、成田多恵、塚原理恵子、中村考伸、飯田絵理、加倉井真樹、梅本尚可、山田朋子、出光俊郎.
    • Organizer
      第34回水疱症研究会
    • Place of Presentation
      青森県弘前市
    • Related Report
      2012 Research-status Report
  • [Presentation] Dsg1陽性の口腔内扁平苔癬の1例.2012

    • Author(s)
      成田多恵、小山尚俊、山田朋子、神谷浩二、青山裕美、出光俊郎
    • Organizer
      第34回水疱症研究会
    • Place of Presentation
      青森県弘前市
    • Related Report
      2012 Research-status Report
  • [Presentation] Handyscope, iphone, iPadを用いたトリコスコピー診療の試み2012

    • Author(s)
      成田多恵、飯田絵理、出光俊郎
    • Organizer
      第17回日本臨床毛髪学会学術大会
    • Place of Presentation
      東京都
    • Related Report
      2012 Research-status Report
  • [Presentation] Handyscope, iphone, iPadを用いたダーモスコピー、トリコスコピー診療の試み

    • Author(s)
      成田多恵、飯田絵理、出光俊郎
    • Organizer
      第39回皮膚かたち研究学会学術大会
    • Place of Presentation
      東京都
    • Related Report
      2012 Research-status Report
  • [Book] 内科で役立つ 一発診断から迫る皮膚疾患の鑑別診断2013

    • Author(s)
      出光俊郎(編)
    • Total Pages
      292
    • Publisher
      羊土社
    • Related Report
      2012 Research-status Report
  • [Book] 内科で出会う 見ためで探す皮膚疾患アトラス2012

    • Author(s)
      出光俊郎(編)
    • Total Pages
      244
    • Publisher
      羊土社
    • Related Report
      2012 Research-status Report
  • [Remarks] 今日の臨床サポート

    • URL

      http://clinicalsup.jp

    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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