Brain development and neurophysiological marker of Autism spectrum disorder in young children
Project/Area Number |
24791206
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Psychiatric science
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Research Institution | Kanazawa University |
Principal Investigator |
YOSHIMURA Yuko 金沢大学, 子どものこころの発達研究センター, 博士研究員 (70597070)
|
Project Period (FY) |
2012-04-01 – 2014-03-31
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
Keywords | 聴覚誘発磁場 / 幼児 / 自閉症スペクトラム障害 |
Research Abstract |
Magnetoencephalography (MEG) is used to measure the auditory evoked magnetic field (AEF), which affects language-related performance. Using the child-customised MEG, we investigated the P50m bilaterally in 35 young children (3 to 7 years old) with autism spectrum disorder (ASD) and 35 typically developing (TD) children. The results showed that the ASD children exhibited significantly less left-hemispheric dominance in P50m intensity compared with the TD children. Furthermore, TD children showed that shorter P50m latency in both hemispheres was specifically correlated with higher language-related performance. However, the ASD children did not show any correlation with language-related performance; instead, increasing chronological age was a significant predictor of shorter P50m latency in the right hemisphere. Our results revealed an atypical brain maturation of the auditory cortex in young children with ASD, regardless of language development.
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Report
(3 results)
Research Products
(12 results)
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[Journal Article] Atypical brain lateralisation in the auditory cortex and language performance in 3- to 7-year-old children with high-functioning autism spectrum disorder : a child-customised magnetoencephalography (MEG) study2013
Author(s)
Y Yoshimura, M Kikuchi, K Shitamichi, S Ueno, T Munesue, Y Ono, T Tsubokawa, Y Haruta, M Oi, Y Niida, GB Remijn, T Takahashi, M Suzuki, H Higashida, Y Minabe
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Journal Title
Mol Autism
Volume: 8巻
Issue: 1
Pages: 38-38
DOI
Related Report
Peer Reviewed
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[Journal Article] The brain's response to the human voice depends on the incidence of autistic traits in the general population2013
Author(s)
Y Yoshimura, M Kikuchi, S Ueno, E Okumura, H Hiraishi, C Hasegawa, G B Remijn, K Shitamichi, T Munesue, T Tsubokawa, H Higashida, Y Minabe
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Journal Title
PLoS One
Volume: 20巻
Issue: 11
Pages: e80126-e80126
DOI
Related Report
Peer Reviewed
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[Journal Article] Language performance and auditory evoked fields in 2- to 5-year-old children2012
Author(s)
Yoshimura, Y., Kikuchi, M., Shitamichi, K., Ueno, S., Remijn, G.B., et al
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Journal Title
European Journal of Neuroscience
Volume: 35
Issue: 4
Pages: 644-650
DOI
Related Report
Peer Reviewed
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