| Project/Area Number |
24791225
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Psychiatric science
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
YOSHII Takanobu 京都府立医科大学, 医学(系)研究科(研究院), 講師 (50468261)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | PTSD / ストレス / 小動物MRI / 神経科学 / MRI / VBM / 動物実験 |
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| Outline of Final Research Achievements |
We seeked bio-marker in PTSD via small animal brain MRI. Single-prolonged stress (SPS: 2hour-restraint, 20min-forced swimming, and ether anesthesia) was applied for PTSD model stress and ex-vivo brain MRI aquisition was conducted. Using voxel-based morphometry, significant 3 atrophic clusters were detected in the sensory area, and thalamus (SPS: n=18, Sham: n=17, cluster-FWE corrected P≦0.). We also conducted immunohistochemistry for IBa-1 as a marker of activated microglia in these areas, and significant increase in IBa-1 immunoreactivity was confirmed. These results suggests that microglial activation may lead to brain atrophy via neuroinnfllamation mechanisms in the paradigm of PTSD model stress.
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