| Project/Area Number |
24791269
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Radiation science
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| Research Institution | Tohoku University |
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Principal Investigator |
JINGU Keiichi 東北大学, 医学(系)研究科(研究院), 教授 (00451592)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 放射線心筋障害 / ナトリウム利尿ペプチド / 放射線心筋障害予防効果 |
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| Outline of Final Research Achievements |
We irradiated to mice's mediastinum with 8 Gy, and then hANP was administrated by continuous intravenous infusion 14 days after irradiation. As control group, we put mice which were not administrated hANP. Six months after irradiation, survived mice were performed MRI and dissected. The group with irradiation showed epicardial thickness and myocardial fibrosis; however, there was no significant differece between the group with irradiation and the group without irradiation. Therefore, hANP was considered to have no protective value for radiation-induced myocardial damage.
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