| Project/Area Number |
24791299
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Radiation science
|
|---|
| Research Institution | Osaka University |
|---|
Principal Investigator |
SAITO Shigeyoshi 大阪大学, 医学(系)研究科(研究院), 助教 (40583068)
|
|---|
| Project Period (FY) |
2012-04-01 – 2014-03-31
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
|---|
| Keywords | 胎生期被ばく / 放射線 / 生体イメージング / マイクロCT / 小動物MRI / 組織染色 / 胎生期放射線曝露 / 高磁場MRI / Micro-CT |
|---|
| Research Abstract |
We assessed brain abnormalities in mice and rats exposed prenatally to radiation (X-rays) using magnetic resonance imaging (MRI), Micro-CT and histological experiments. These animals were exposed to different radiation doses (0.5, 1.0, and 1.5 Gy). Brain abnormalities were assessed in neonatal male mice and rats. In vivo/Ex vivo T2-weighted imaging and diffusion tensor imaging (DTI) were performed using 11.7 T MRI. Decreased brain volume, increased ventricle volume, and thinner cortices were observed in irradiated rats and mice using MRI. However, no abnormalities in the cortical 6-layered structure were observed in radiation-exposed mice and rats. T2W and DTI and histological experiments are useful tools for assessing cortical and hippocampal abnormalities after prenatal exposure to radiation in mice and rats.
|
