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Non-invasive assessment of mouse brain tumor by EPR imaging

Research Project

Project/Area Number 24791318
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Radiation science
Research InstitutionSapporo Medical University

Principal Investigator

EMOTO Miho  札幌医科大学, 医療人育成センター, 研究員 (10578735)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
KeywordsEPRイメージング / MRI / 酸化還元 / 酸化ストレス / 分子イメージング
Research Abstract

Electron paramagnetic resonance (EPR) imaging is a noninvasive imaging method for visualizing redox status using nitroxide as an imaging probe.In this project, using an improved EPR imaging system, I showed the distribution and redox status in mouse brain by using some nitroxides, which have five-membered ring or six-membered ring. Three-dimensional EPR image was obtained in about 15 sec from 181 projection data. This data acquisition time was fast enough to visualize and evaluate pharmacokinetics of some nitroxides used in this project. Further, we obtained anatomical information of mouse brain with MRI. By superimposed EPR image on MRI, i clarified behavior of some nitroxides in mouse brain.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (28 results)

All 2013 2012

All Journal Article (13 results) (of which Peer Reviewed: 13 results) Presentation (15 results)

  • [Journal Article] Novel ascorbic acid-resistive nitroxide in a lipid emulsion: An efficient brain imaging contrast agent for MRI of small rodents.2013

    • Author(s)
      Emoto MC, Yamada KI, Yamato M, Fujii HG.
    • Journal Title

      Neurosci Lett.

      Volume: 546 Pages: 11-15

    • DOI

      10.1016/j.neulet.2013.04.044

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Noninvasive mapping of the redox status in septic mouse by in vivo electron paramagnetic resonance imaging.2013

    • Author(s)
      Hirotada Fujii
    • Journal Title

      Magnetic Resonance Imaging

      Volume: 31 Issue: 1 Pages: 130-138

    • DOI

      10.1016/j.mri.2012.06.021

    • Related Report
      2013 Annual Research Report 2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Redox Mapping in LPS-Treated Mouse Brain by Using Three-Dimensional EPR Imaging System2013

    • Author(s)
      Miho C Emoto, Hideo Sato-Akaba, Hiroshi Hirata, and Hirotada G Fujii
    • Journal Title

      Free Radical Biology and Medicine

      Volume: s45 Pages: IFC-IFC

    • DOI

      10.1016/s0891-5849(12)01715-7

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Redox map of mouse brain by three-dimensional EPR imaging with six-membered nitroxyl radicals2013

    • Author(s)
      MC Emoto, H Sato-Akaba, H Hirata, HG Fujii
    • Journal Title

      Proc. Intl. Soc. Mag. Reson. Med

      Volume: 21 Pages: 1986-1986

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Brain Redox Mapping in Methanphetamine-treated Mice using Tree-Dimensional EPR Imaging2013

    • Author(s)
      HG Fujii, MC Emoto, M Yamato, KI Yamada
    • Journal Title

      Proc.Intl.Soc.Mag.Reson.Med

      Volume: 21 Pages: 1987-1987

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Redox map of mouse brain by three-dimensional EPR imaging with six-membered nitroxyl radicals.2013

    • Author(s)
      MC Emoto, H Sato-Akaba, H Hirata, HG Fujii
    • Journal Title

      Proc.Intl.Soc.Mag.Reson.Med.

      Volume: 21 Pages: 1986-1986

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Redox Mapping in LPS-Treated Mouse Brain by Using Three-Dimensional EPR Imaging System2013

    • Author(s)
      Miho C Emoto, Hideo Sato-Akaba, Hiroshi Hirata, and Hirotada G Fujii
    • Journal Title

      Free Radical Biology and Medicine

      Volume: 65 Pages: S45-S45

    • DOI

      10.1016/j.freeradbiomed.2013.10.495

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Difference in distribution and reduction rate of BBB permeable nitroxides by in vivo EPR imaging method2012

    • Author(s)
      MC Emoto, H Sato-Akaba, H Hirata, HG Fujii
    • Journal Title

      Free Radical Biology and Medicine

      Volume: 53 Pages: S65-S65

    • DOI

      10.1016/j.freeradbiomed.2012.10.195

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Distribution and time course of Blood-Brain Barrier-permeable nitroxides in mouse head by MRI and EPR imaging2012

    • Author(s)
      MC Emoto, H Sato-Akaba, H Hirata, HG Fujii
    • Journal Title

      Proc. Intl. Soc. Mag. Reson. Med

      Volume: 20 Pages: 1709-1709

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] EPR–MRI studies of small rodents by the use of paramagnetic compounds2012

    • Author(s)
      Fujii H, Emoto M
    • Journal Title

      Folia Pharmacologica Japonica

      Volume: 140 Issue: 4 Pages: 156-160

    • DOI

      10.1254/fpj.140.156

    • NAID

      10031072208

    • ISSN
      0015-5691, 1347-8397
    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Magnetic Resonance-based molecular imaging studies of mice by using paramagnetic contrast probes2012

    • Author(s)
      Hirotada Fujii, Miho Emoto
    • Journal Title

      Journal of Pharmacological Science

      Volume: 118 Pages: 16-16

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Distribution and time course of Blood Brain Barrier-permeable nitroxides in mouse head by MRI and EPR imaging2012

    • Author(s)
      Miho C Emoto, Hideo Sato-Akaba, Hiroshi Hirata, and Hirotada G Fujii
    • Journal Title

      Proc.Intl.Soc.Mag.Reson.Med.

      Volume: 20 Pages: 1709-1709

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Differences in Distribution and Reducton Rate of BBB Permeable Nitorixides by in Vivo EPR Imaging Method2012

    • Author(s)
      Miho C Emoto, Hideo Sato-Akaba, Hiroshi Hirata, and Hirotada G Fujii
    • Journal Title

      Free Radical Biology and Medicine

      Volume: 53

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] Redox Mapping in LPS-Treated Mouse Brain byUsing Three-Dimensional EPR Imaging System2013

    • Author(s)
      Miho C Emoto, Hideo Sato-Akaba, Hiroshi Hirata, and Hirotada G Fujii
    • Organizer
      フリーラジカル生物医学会議
    • Place of Presentation
      サンアントニオ アメリカ合衆国
    • Year and Date
      2013-11-21
    • Related Report
      2013 Final Research Report
  • [Presentation] 血液脳関門透過性 nitroxide を用いたマウス頭部の高速EPR イメージングとMRI2013

    • Author(s)
      江本美穂・赤羽英夫・平田拓・藤井博匡
    • Organizer
      電子スピンサイエンス学会
    • Place of Presentation
      大宮ソニックシティ
    • Year and Date
      2013-10-24
    • Related Report
      2013 Final Research Report
  • [Presentation] 高速EPRイメージング法を用いた酸化ストレスを可視化する分子イメージング手法の開発2013

    • Author(s)
      江本美穂・赤羽英夫・平田拓・藤井博匡
    • Organizer
      日本磁気共鳴医学会
    • Place of Presentation
      アスティ徳島
    • Year and Date
      2013-09-19
    • Related Report
      2013 Final Research Report
  • [Presentation] Redox map of mouse brain by three-dimensional EPR imaging with six-membered nitroxyl radicals2013

    • Author(s)
      MC Emoto, H Sato-Akaba, H Hirata, HG Fujii
    • Organizer
      国際磁気共鳴医学会
    • Place of Presentation
      ソルトレイクシティー アメリカ合衆国
    • Year and Date
      2013-04-25
    • Related Report
      2013 Final Research Report
  • [Presentation] Brain Redox Mapping in Methanphetamine-treated Mice using Tree-Dimensional EPR Imaging2013

    • Author(s)
      HG Fujii, MC Emoto, M Yamato, KI Yamada.
    • Organizer
      The International Society for Magnetic Resonance in Medicine
    • Place of Presentation
      Salt Palace Convention Center
    • Related Report
      2013 Annual Research Report
  • [Presentation] Redox map of mouse brain by three-dimensional EPR imaging with six-membered nitroxyl radicals.2013

    • Author(s)
      MC Emoto, H Sato-Akaba, H Hirata, HG Fujii.
    • Organizer
      The International Society for Magnetic Resonance in Medicine
    • Place of Presentation
      Salt Palace Convention Center
    • Related Report
      2013 Annual Research Report
  • [Presentation] Redox Mapping in LPS-Treated Mouse Brain by Using Three-Dimensional EPR Imaging System2013

    • Author(s)
      Miho C Emoto, Hideo Sato-Akaba, Hiroshi Hirata, and Hirotada G Fujii
    • Organizer
      The Society for Free Radical Biology and Medicine
    • Place of Presentation
      Grand Hyatt San Antonio
    • Related Report
      2013 Annual Research Report
  • [Presentation] In vivo Imaging of Redox Status and Blood Brain Barrier Function in Methamphetamine-Treated Mouse Brain2013

    • Author(s)
      Hirotada G Fujii, Miho C Emoto, Mayumi Yamato, and Ken-ichi Yamada
    • Organizer
      The Society for Free Radical Biology and Medicine
    • Place of Presentation
      Grand Hyatt San Antonio
    • Related Report
      2013 Annual Research Report
  • [Presentation] 高速EPRイメージング法を用いた酸化ストレスを可視化する分子イメージング手法の開発2013

    • Author(s)
      江本美穂、赤羽英夫、平田拓、藤井博匡
    • Organizer
      日本磁気共鳴医学会
    • Place of Presentation
      アスティとくしま
    • Related Report
      2013 Annual Research Report
  • [Presentation] MC Emoto, H Sato-Akaba, H Hirata, HG Fujii2012

    • Author(s)
      Difference in distribution and reduction rate of BBB permeable nitroxides by in vivo EPR imaging method
    • Organizer
      フリーラジカル生物医学会議
    • Place of Presentation
      サンディエゴ アメリカ合衆国
    • Year and Date
      2012-11-15
    • Related Report
      2013 Final Research Report
  • [Presentation] EPR イメージングによる六員環ニトロキシドのマウス頭部における酸化還元状態の評価2012

    • Author(s)
      江本美穂・赤羽英夫・平田拓・藤井博匡
    • Organizer
      電子スピンサイエンス学会
    • Place of Presentation
      札幌コンベンションセンター
    • Year and Date
      2012-11-03
    • Related Report
      2013 Final Research Report
  • [Presentation] Distribution and time course of Blood-Brain Barrier-permeable nitroxides in mouse head by MRI and EPR imaging2012

    • Author(s)
      MC Emoto, H Sato-Akaba, H Hirata, HG Fujii
    • Organizer
      国際磁気共鳴医学会
    • Place of Presentation
      メルボルン オーストラリア
    • Year and Date
      2012-05-08
    • Related Report
      2013 Final Research Report
  • [Presentation] Distribution and time course of Blood Brain Barrier-permeable nitroxides in mouse head by MRI and EPR imaging2012

    • Author(s)
      Miho C Emoto, Hideo Sato-Akaba, Hiroshi Hirata, and Hirotada G Fujii
    • Organizer
      The International Society for Magnetic Resonance in Medicine
    • Place of Presentation
      メルボルンコンベンションセンター
    • Related Report
      2012 Research-status Report
  • [Presentation] EPRイメージングによる六員環ニトロキシドのマウス頭部における酸化還元状態の評価2012

    • Author(s)
      江本美穂、赤羽英夫、平田拓、藤井博匡
    • Organizer
      電子スピンサイエンス学会
    • Place of Presentation
      札幌コンベンションセンター
    • Related Report
      2012 Research-status Report
  • [Presentation] Differences in Distribution and Reducton Rate of BBB Permeable Nitorixides by in Vivo EPR Imaging Method2012

    • Author(s)
      Miho C Emoto, Hideo Sato-Akaba, Hiroshi Hirata, and Hirotada G Fujii
    • Organizer
      Society of Free Radical Biology and Medicine
    • Place of Presentation
      Hilton San Diego Bayfront
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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