Immunoenhancing effect by low dose radiation exposure in combination of the dendritic cells
| Project/Area Number |
24791323
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Radiation science
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| Research Institution | Nagoya City University |
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Principal Investigator |
Kawai Tatsuya 名古屋市立大学, 医学(系)研究科(研究院), 助教 (70597822)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 低用量放射線 / 免疫療法 / 低容量放射線 / 放射線治療 / 免疫治療 |
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| Outline of Final Research Achievements |
We investigated the effect of low dose X ray irradiation on the immune system by using mouse models. There were no significant difference in population of the lymphocytes; CD4+ T cells, CD8+ T cells, NK/NKT cells, and regulatory T cells by a single total body irradiation between 50 mGy and 200 mGy compared to the control group. On the other hand, an increase in antigen-specific CD8+ T cells was observed in continuous radiation exposed model mice (25 mGy x 10 days) immunized by ovalbumin. In conclusion, it was suggested that long term, low dose systemic radiation exposure might enhance specific cellular immunity.
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Report
(5 results)
Research Products
(9 results)
