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Early prediction of tumor effect for anti-angiogenic therapy in liver metastasis on ECR images

Research Project

Project/Area Number 24791328
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Radiation science
Research InstitutionNara Medical University

Principal Investigator

NISHIOFUKU Hideyuki  奈良県立医科大学, 医学部, 助教 (80458041)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords核磁気共鳴画像 / Interventional radiology / 分子イメージング / MRI / 肝腫瘍 / 分子標的薬 / ECRI / 個別化医療
Research Abstract

To investigate whether ECRI is useful for early prediction of the response to chemotherapy for hepatic colorectal metastases. Chemotherapy-naive 9 patients with hepatic colorectal metastases were enrolled. ECRI were performed before and 2 weeks after initiating chemotherapy. The single saturation transfer pulse frequency was employed at the frequency 3.5 ppm downfield from the water resonance. The ECR value was defined as the percentage of signal loss between unsaturated and saturated images. The ECR value was compared with change in tumor size. Seven patients achieved PR, 2 patients SD. In 13 lesions of 7 PR cases, the mean ECR value before and 2 weeks after was 43.6% and 32.1%, the mean tumor size was 4.3cm and 3.9cm. In 4 lesions of 2 SD, the mean ECR value was 31.3% and 20.9%. The ECR value before initiating chemotherapy is likely to have relation to early prediction of the response.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (8 results)

All 2014 2013 Other

All Presentation (6 results) Remarks (2 results)

  • [Presentation] 大腸癌肝転移に対すベバシズマブ療法の早期治療効果予測におけるECR 画像の初期経験2014

    • Author(s)
      佐藤健司, 西尾福英之
    • Organizer
      第41回日本磁気共鳴医学会
    • Place of Presentation
      徳島県
    • Related Report
      2013 Final Research Report
  • [Presentation] 大腸癌肝転移に対すベバシズマブ療法の早期治療効果予測におけるECR 画像の初期経験2014

    • Author(s)
      佐藤健司, 西尾福英之
    • Organizer
      第49回日本医学放射線学会秋季臨床大会
    • Place of Presentation
      名古屋
    • Related Report
      2013 Final Research Report
  • [Presentation] Technical Recommendations for Intra-arterial Therapy in Rat Liver Tumor Model2013

    • Author(s)
      Hideyuki Nishiofuku, Toshihiro Tanaka, et al
    • Organizer
      RSNA
    • Place of Presentation
      Chicago
    • Related Report
      2013 Final Research Report
  • [Presentation] Early detection of the response to systemic chemotherapy for liver metastases from colorectal cancer using equivalent cross-relaxation rate imaging2013

    • Author(s)
      佐藤健司
    • Organizer
      第72回日本医学放射線学会総会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2012 Research-status Report
  • [Presentation] 大腸癌肝転移に対するベバシズマブ療法の早期治療効果予測におけるECR画像の初期経験2013

    • Author(s)
      佐藤健司
    • Organizer
      第37回日本磁気共鳴医学会大会
    • Place of Presentation
      アスティとくしま
    • Related Report
      2012 Research-status Report
  • [Presentation] 大腸癌肝転移に対するベバシズマブ療法の早期治療効果予測におけるECR画像の初期経験2013

    • Author(s)
      西尾福英之
    • Organizer
      第49回日本医学放射線学会秋季臨床大会
    • Place of Presentation
      名古屋国際会議場
    • Related Report
      2012 Research-status Report
  • [Remarks]

    • URL

      http://www.nara-radiology.com

    • Related Report
      2013 Final Research Report
  • [Remarks] 奈良県立医科大学放射線科

    • URL

      http://www.nara-radiology.com

    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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