The study of change in acute ischemic stroke used by a new diffusion MRI metric: QSI/DKI

• Project/Area Number: 24791339
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: Juntendo University
• Principal Investigator: TANAKA Fumine 順天堂大学, 医学部, 助手 (70621738)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: MRI / 脳梗塞 / DKI / 脳梗塞拡散画像 / QSI/DKI

Research Abstract

Subjects were 27 stroke patients presenting with cerebral white matter, cortex, cerebellum, brainstem or basal ganglia infarction (time after onset= 3hours~29days). All subjects were scanned Diffusional kurtosis imaging (DKI) that is more advanced diffusional imaging and diffusion tensor imaging (DTI) that is conventional diffusional imaging on 1.5T MR scanner. Regions of interest were defined for each stroke lesion. Parameter of DKI: mean diffusional kurtosis (MDK) and DTI parameters were calculated. In result, it indicates that MDK add pathological information differing from DTI. In short, the value of MDK indicates complexity of the tissue. It helps us to understand pathological change of stroke lesion. And MDK map can predict the outcome of stroke lesion 1 month earlier than conventional diffusional imaging.

Research Products

• [Presentation] 急性期脳梗塞白質病変におけるDiffusion Tensor Imaging とDiffusional Kurtosis Imaging の検討 (2013)
  • Author(s): 斎藤史根, 朝日公一, 鈴木通真, 福永一星, 磯野沙智子, 京極伸介, 堀正明, 卜部貴夫, 増谷佳孝, 青木茂樹
  • Organizer: 第72回日本医学放射線学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2013-04-13
• [Presentation] Preliminary experience of diffusional kurtosis imaging for acute brain infarction (2013)
  • Author(s): F. Saito
  • Organizer: ECR (Europian Congress of Radiology)
  • Place of Presentation: Austria Center Vienna
• [Presentation] Preliminary experience of diffusional kurtosis imaging for acute brain infarction (2013)
  • Author(s): F.Saito
  • Organizer: Europian Congress of Radiology 2013
  • Place of Presentation: オーストリア、ウィーン
• [Presentation] 急性期脳梗塞におけるDiffusional Kurtosis Imaging の初期経験 (2012)
  • Author(s): 斎藤史根, 鈴木通真, 福永一星, 小泉達也, 小林祥, 北條昇, 北村直也, 磯野沙智子, 京極伸介, 堀正明, 卜部貴夫, 増谷佳孝, 青木茂樹
  • Organizer: 第39回日本磁気共鳴医学会大会
  • Place of Presentation: 京都
  • Year and Date: 2012-09-07
• [Presentation] 急性期脳梗塞白質病変におけるDiffusion Tensor ImagingとDiffusional Kurtosis Imagingの検討
  • Author(s): 斎藤史根、朝日公一、鈴木通真、福永一星、磯野沙智子、京極伸介、堀正明、卜部貴夫、増谷佳孝、青木茂樹
  • Organizer: 第72回日本医学放射線学会総会
  • Place of Presentation: 横浜
• [Presentation] 急性期脳梗塞におけるDiffusional Kurtosis Imagingの初期経験
  • Author(s): 斎藤史根、鈴木通真、福永一星、小泉達也、小林祥、北條昇、北村直也、磯野沙智子、京極伸介、堀正明、卜部貴夫、増谷佳孝、青木茂樹
  • Organizer: 第39回日本磁気共鳴医学会大会
  • Place of Presentation: 京都