Feasibility study for production of Tc-99m by using a medical cyclotron.
| Project/Area Number |
24791355
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Radiation science
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| Research Institution | National Institute of Radiological Sciences |
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Principal Investigator |
NAGATSU Kotaro 独立行政法人放射線医学総合研究所, 分子イメージング研究センター, 主任研究員 (30531529)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | テクネチウム99m / 医療用加速器 / モリブデン99 / テクネチウム-99m / 医療用小型加速器 |
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| Research Abstract |
To combat the Mo-99/Tc-99m crisis in Japan, we are proposing a small-scale direct Tc-99m production by using a medical cyclotron. We developed an automated Tc-99m production system with satisfaction of both easy-operability and low radiation exposure during the process including target preparation.
The Tc-99m yield reached to about 6 to 8 mCi/micro-Ah at the end of bombardment, and [Tc-99m]TcO4- with >99% radiochemical purity was successfully obtained within 75 min by using two chelating-columns purification. The cyclotron-based Tc-99m production method has a potential to be an alternative of the conventional reactor-based Mo-99/Tc-99m supply.
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Report
(3 results)
Research Products
(2 results)
