Feasibility study for production of Tc-99m by using a medical cyclotron.

Research Project

Project/Area Number	24791355
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Radiation science
Research Institution	National Institute of Radiological Sciences
Principal Investigator	NAGATSU Kotaro 独立行政法人放射線医学総合研究所, 分子イメージング研究センター, 主任研究員 (30531529)
Project Period (FY)	2012-04-01 – 2014-03-31
Project Status	Completed (Fiscal Year 2013)
Budget Amount *help	¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000) Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords	テクネチウム99m / 医療用加速器 / モリブデン99 / テクネチウム-99m / 医療用小型加速器
Research Abstract	To combat the Mo-99/Tc-99m crisis in Japan, we are proposing a small-scale direct Tc-99m production by using a medical cyclotron. We developed an automated Tc-99m production system with satisfaction of both easy-operability and low radiation exposure during the process including target preparation. The Tc-99m yield reached to about 6 to 8 mCi/micro-Ah at the end of bombardment, and [Tc-99m]TcO4- with >99% radiochemical purity was successfully obtained within 75 min by using two chelating-columns purification. The cyclotron-based Tc-99m production method has a potential to be an alternative of the conventional reactor-based Mo-99/Tc-99m supply.