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Feasibility study for production of Tc-99m by using a medical cyclotron.

Research Project

Project/Area Number 24791355
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Radiation science
Research InstitutionNational Institute of Radiological Sciences

Principal Investigator

NAGATSU Kotaro  独立行政法人放射線医学総合研究所, 分子イメージング研究センター, 主任研究員 (30531529)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywordsテクネチウム99m / 医療用加速器 / モリブデン99 / テクネチウム-99m / 医療用小型加速器
Research Abstract

To combat the Mo-99/Tc-99m crisis in Japan, we are proposing a small-scale direct Tc-99m production by using a medical cyclotron. We developed an automated Tc-99m production system with satisfaction of both easy-operability and low radiation exposure during the process including target preparation.
The Tc-99m yield reached to about 6 to 8 mCi/micro-Ah at the end of bombardment, and [Tc-99m]TcO4- with >99% radiochemical purity was successfully obtained within 75 min by using two chelating-columns purification. The cyclotron-based Tc-99m production method has a potential to be an alternative of the conventional reactor-based Mo-99/Tc-99m supply.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (2 results)

All 2013

All Presentation (2 results)

  • [Presentation] 医療用小型加速器によるTc-99m の遠隔製造法の開発2013

    • Author(s)
      永津弘太郎, 峯岸克行, 張明栄
    • Organizer
      第53回日本核医学会学術総会
    • Place of Presentation
      福岡国際会議場
    • Related Report
      2013 Final Research Report
  • [Presentation] 医療用小型加速器によるTc-99mの遠隔製造法の開発2013

    • Author(s)
      永津弘太郎,峯岸克行,張明栄
    • Organizer
      第53回日本核医学会学術総会
    • Place of Presentation
      福岡国際会議場
    • Related Report
      2013 Annual Research Report

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Published: 2013-05-31   Modified: 2019-07-29  

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