PET imaging for blood-brain barrier

• Project/Area Number: 24791356
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: National Institute of Radiological Sciences
• Principal Investigator: OKADA Maki 独立行政法人放射線医学総合研究所, 分子イメージング研究センター, 研究員 (00415407)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: PET / 血液脳関門 / アミノイソ酪酸 / 収束超音波 / メチルアミノイソ酪酸

Outline of Final Research Achievements

We visualized the blood-brain barrier (BBB) opening by 11C-2-aminoisobutyric acid (P11PC-AIB) PET. 11C-AIB significantly and gradually accumulated the BBB-opening side compared with contralateral side. Moreover, the 11C-AIB accumulated area was co-localized with the area stained by Evans blue, the marker of BBB breakdown. The kinetic of 11C-AIB in brain was different from that of Gd-DTPA-enhanced MRI. These results suggest that 11C-AIB PET is a useful method for visualizing BBB opening. However, the accumulating mechanism of 11C-AIB PET is different from that of Gd-DTPA-enhanced MRI.

Research Products

• [Presentation] 2-Amino-[3-11C]isobutyric acid PETを用いた収束超音波-マイクロバブルによる血液脳関 (2014)
  • Author(s): 岡田 真希, 辻 厚至, 菊池 達矢, 脇坂 秀克, 岡村 敏充, 加藤 孝一, 張 明栄.
  • Organizer: 第54回日本核医学会学術総会
  • Place of Presentation: 大阪国際会議場・大阪市
  • Year and Date: 2014-11-06 – 2014-11-08
• [Presentation] PET imaging with 2-amino-[3-11C]isobutyric acid for the assessment of blood-brain barrier opening induced by focused ultrasound in the rat. (2014)
  • Author(s): Maki Okada, Atsushi Tsuji, Tatsuya Kikuchi, Hidekatsu Wakizaka, Toshimitsu Okamura, Koichi Kato, Ming-Rong Zhang.
  • Organizer: the 11th Congress of the World Federation of Nuclear Medicine and Biology, World Federation of Nuclear Medicine and Biology
  • Place of Presentation: Cancun, Mexico
  • Year and Date: 2014-08-27 – 2014-08-31
• [Presentation] [3-11C]AIBおよび[11C]MeAIBによる血液脳関門の高感度PETイメージング (2013)
  • Author(s): 岡田 真希, 辻 厚至, 菊池 達矢, 脇坂 秀克, 岡村 敏充, 加藤 孝一, 張 明栄
  • Organizer: 第53回日本核医学会学術総会
  • Place of Presentation: 福岡市，福岡
• [Presentation] n Vivo Imaging of Blood-brain Barrier Permeability with 2-Amino-[3-11C]isobutyric Acid by Positron Emission Tomography (2012)
  • Author(s): Maki Okada, Atsushi B Tsuji, Tatsuya Kikuchi, Hidekatsu Wakizaka, Toshimitsu Okamura, Ming-Rong Zhang, Toshimitsu Fukumura, Koichi Kato
  • Organizer: World Molecular Imaging Congress 2012
  • Place of Presentation: Dublin. Ireland
• [Presentation] 2-Amino-[3-11C]isobutyric acidによる血液脳関門の高感度PETイメージング (2012)
  • Author(s): 岡田 真希, 辻 厚至, 菊池 達矢, 脇坂 秀克, 岡村 敏充, 張 明栄, 加藤 孝一
  • Organizer: 第52回日本核医学会学術総会
  • Place of Presentation: 札幌市，北海道