PET imaging for blood-brain barrier
Project/Area Number |
24791356
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Radiation science
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Research Institution | National Institute of Radiological Sciences |
Principal Investigator |
OKADA Maki 独立行政法人放射線医学総合研究所, 分子イメージング研究センター, 研究員 (00415407)
|
Project Period (FY) |
2012-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | PET / 血液脳関門 / アミノイソ酪酸 / 収束超音波 / メチルアミノイソ酪酸 |
Outline of Final Research Achievements |
We visualized the blood-brain barrier (BBB) opening by 11C-2-aminoisobutyric acid (P11PC-AIB) PET. 11C-AIB significantly and gradually accumulated the BBB-opening side compared with contralateral side. Moreover, the 11C-AIB accumulated area was co-localized with the area stained by Evans blue, the marker of BBB breakdown. The kinetic of 11C-AIB in brain was different from that of Gd-DTPA-enhanced MRI. These results suggest that 11C-AIB PET is a useful method for visualizing BBB opening. However, the accumulating mechanism of 11C-AIB PET is different from that of Gd-DTPA-enhanced MRI.
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Report
(4 results)
Research Products
(5 results)