| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
In this project, we found that activation of IL-6 signal(STAT3)are involved in the pathogenesis of murine and human aortic aneurysm, and also that in mice, STAT3 activation in smooth muscle cells are associated with apoptosis and proliferation. However, the IL-6 signal in smooth muscle cells did not affect the formation of experimental aortic aneurysm, and revealed that it is not critical to the aneurysm pathology. On the other hand, in the aortic dissection, knocking out smooth muscle's STAT3 showed greater susceptibility upon the BAPN and angiotensin infusion compared to wild type mice. Thus, we found a new insights, suggests that smooth muscle's STAT3 may play an important role in aortic dissection pathology.
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