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Postoperative Atrial Fibrillation and Insulin Resistance

Research Project

Project/Area Number 24791453
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Thoracic surgery
Research InstitutionHokkaido University

Principal Investigator

Shingu Yasushige  北海道大学, 大学病院, 助教 (30617064)

Project Period (FY) 2012-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2015: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2014: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Keywords術後心房細動 / インスリン抵抗性 / 脂肪酸代謝 / 心房細動
Outline of Final Research Achievements

Subjects were 38 patients who underwent cardio-thoracic surgery. Twenty-four-hours monitoring by electrocardiogram was conducted for the detection of postoperative atrial fibrillation for 7 days after surgery. Excised right atrial muscle was quickly frozen and stored for the gene expression analysis of glucose and fatty acid metabolism. Eighteen patients (47%) presented with postoperative atrial fibrillation (POAF group). The gene expression of fatty acid binding protein 3 (FABP3: fatty acid transporter in myocytes) was significantly reduced in the POAF group than in the non-POAF group. Moreover, in the analysis of 12 patients with insulin resistance, the gene expression of fatty acid translocase (CD36: fatty acid transporter into myocytes) tended to be higher in the POAF group than in the non-POAF group (P=0.08). We demonstrated that there is a correlation between POAF and abnormal gene expression of fatty acid metabolism in the myocardium.

Report

(5 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (1 results)

All 2013

All Presentation (1 results)

  • [Presentation] 術後心房細動患者では術後心筋興奮ー収縮連関時間が延長している2013

    • Author(s)
      新宮 康栄
    • Organizer
      日本外科学会
    • Place of Presentation
      福岡国際会議場(福岡市)
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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