| Project/Area Number |
24791464
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Thoracic surgery
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| Research Institution | Kyushu University |
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Principal Investigator |
HARO Akira 九州大学, 大学病院, その他 (90546558)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 原発性非小細胞肺癌 / 肺組織幹細胞 / 原発性肺癌 / 癌幹細胞 |
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| Research Abstract |
We investigated the roles of lung stem cell genes in primary lung carcinoma using human primary lung carcinoma tissues.
(1) We showed that mRNA expression of Sox9, N-myc, FoxA1, CD133 and Id2 in lung carcinoma tissues was higher than in normal lung tissues. (2) We showed that protein of Id2 gene was expressed in 52% of lung adenocarcinoma (12/23 cases), in 14% of lung squamous cell carcinomas (12/23 cases). There was no protein expression of Id2 gene in small cell lung carcinoma (0/6). Id2 gene was not a significant prognosis factor. The protein had a significant associations to adenocarcinoma histology, well deferentiated histology and pT1 stage. Furthermore, expression of CD133 gene had no associations to clinicopathological factors. However, CD133 gene was a poor prognostic factor in 5-years overall survival and 5-years disease free survival. These results insist that CD133 gene should have an important role in recurrence and metastasis of human primary lung carcinoma.
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