Development of novel immunotherapy using combination of inactivated viral particle and autologous tumor vaccine for malignant glioma

• Project/Area Number: 24791485
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Cerebral neurosurgery
• Research Institution: University of Tsukuba
• Principal Investigator: MATSUDA Masahide 筑波大学, 医学医療系, 講師 (30614333)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 不活化ウイルス粒子 / 自家腫瘍ワクチン / 脳腫瘍 / 新規免疫療法

Outline of Final Research Achievements

Hemagglutinating virus of Japan envelope (HVJ-E) derived from inactivated replication-defective Sendai virus was originally developed as a versatile drug delivery system. We had shown the ability of HVJ-E itself to enhance anti-tumor immunity through activation of effector T cells and natural killer cells and inhibition of regulatory T cells in glioma mouse models. In the present study, we have shown that the addition of systemic activation of tumor specific immunity by autologous tumor vaccination to local inhibition of immune tolerance by HVJ-E leads to synergistic activation of anti-tumor immunity against intracranial glioma.

Research Products

• [Presentation] 悪性グリオーマに対する不活化ウイルス粒子と自家腫瘍ワクチンの併用療法 (2014)
  • Author(s): 小沼邦之、松田真秀
  • Organizer: 第32回日本脳腫瘍学会学術集会
  • Place of Presentation: 千葉
  • Year and Date: 2014-11-30 – 2014-12-02
• [Presentation] 悪性神経膠腫に対するnon-replicating oncolytic vector therapyの自家腫瘍ワクチンによる増強効果 (2014)
  • Author(s): 小沼邦之、松田真秀
  • Organizer: 第11回がんワクチン療法研究会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2014-11-22
• [Presentation] 悪性グリオーマに対する不活化ウイルス粒子と自家腫瘍ワクチンの併用療法 (2014)
  • Author(s): 小沼邦之、松田真秀
  • Organizer: 日本脳神経外科学会第73回学術総会
  • Place of Presentation: 東京
  • Year and Date: 2014-10-09 – 2014-10-11
• [Presentation] Development of inactivated viral particle therapy for malignant glioma (2014)
  • Author(s): Onuma K, Matsuda M
  • Organizer: 11th Meeting of Asian Society for Neuro-Oncology
  • Place of Presentation: Istanbul,Turkey
  • Year and Date: 2014-09-11 – 2014-09-14
• [Presentation] 悪性神経膠腫に対するnon-replicating oncolytic vector therapyの開発 (2013)
  • Author(s): 松田 真秀
  • Organizer: 第31回日本脳腫瘍学会学術集会
  • Place of Presentation: フェニックス・シーガイア・リゾート（宮崎県）