Basic base constraction of malignant glioma therapy targeting for GSK3beta
| Project/Area Number |
24791491
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
NAKADA Mitsutoshi 金沢大学, 医学系, 講師 (20334774)
TANAKA Shingo 金沢大学, 医学系, 協力研究員 (40507084)
FUROTA Takuya 金沢大学, 大学病院, 医員 (20646690)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | glioblastoma / GSK3beta / グリオブラストーマ / 分子標的治療 |
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| Research Abstract |
We focus on the glycogen synthase kinase 3beta,serine-threonine kinase family, demonstrated that inhibition of GSK3beta supresses proliferation and invasion of glioblastoma cells ,and increases the effect of anti-cancer drugs synergistically. In the study using a mouse tumor model, we demonstrated tumor growth inhibitory effect of GSK3be-ta inhibition in vivo. We reported that GSK3be-ta inhibition sensitizes human glioblastoma cells to temozolomide by affecting O6-methylguanine DNA methyltransferase promoter methylation via c-Myc signaling. In addition, using existing drugs with GSK3be-ta inhibitory effect, we conducted clinical trial for recurrent glioblastoma.
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Report
(3 results)
Research Products
(12 results)
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[Presentation] 再発膠芽腫治療に対してGSK3β 阻害作用を有する既存薬剤を用いた単施設第I・II 相臨床試験2012
Author(s)
宮下勝吉, 中田光俊, 林 裕, 木下雅史, 古田拓也, 淑瑠ヘムラサビット, 渡邉卓也, 喜多大輔, 林 康彦, 内山尚之, 川上和之, 源 利成, 濵田潤一郎
Organizer
第30回日本脳腫瘍学会学術総会
Place of Presentation
広島
Related Report
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[Presentation] 再発神経膠芽腫に対してGSK3β 阻害作用を有する既存薬剤を用いた第I・II 相臨床試験における剖検例の免疫組織学的検討2012
Author(s)
宮下勝吉, 中田光俊, 林 裕, 渡邉卓也, 木下雅史, 古田拓也, 淑瑠ヘムラサビット, 喜多大輔, 林康彦, 内山尚之, 川上和之, 源利成, 濵田潤一郎
Organizer
第71回日本脳神経外科学会総会
Place of Presentation
大阪
Related Report
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