A network alteration analysis in the central nervous system disorders
| Project/Area Number |
24791500
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Osaka University |
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Principal Investigator |
TANI Naoki 大阪大学, 医学(系)研究科(研究院), 特任研究員 (20598370)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
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| Keywords | Default mode network / Restina stage network / 機能的結合 / 側頭葉てんかん / 正常圧水頭症 / 後部帯状回 / 言語性記憶障害 / 安静時functional MRI / default mode network / Functional connectivity / Resting state network / Temporal lobe epilepsy / Parkinson's disease / NPH |
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| Outline of Final Research Achievements |
In the normal healthy subject, we found a strong negative functional connectivity between posterior cingulate cortex, which is one of the important hubs of the default mode network, and the inferior frontal gyrus. This negative functional connectivity has attenuated in the temporal lobe epilepsy patient with verbal memory impairment. However, it is unclear whether this attenuation emerges as the result of the verbal memory impairment or plays a role in causing the verbal memory impairment.
Additionally, we found an alteration in the DMN of patients with iNPH. We showed that the DMN connectivity was reduced in patients with iNPH and it correlated with the severity of their clinical symptoms. The reduction may be reflecting an adaptive response of patients against their impairments.
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Report
(4 results)
Research Products
(65 results)
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[Journal Article] Default mode network connectivity in patients with idiopathic normal pressure hydrocephalus2015
Author(s)
Hui Ming Khoo, Haruhiko Kishima, Naoki Tani, Satoru Oshino, Tomoyuki Maruo, Koichi Hosomi, Takufumi Yanagisawa, Hiroaki Kazui, Yoshiyuki Watanabe, Toshio Shimokawa, Toshihiko Aso. Atsuhi Kawaguchi, Fumio Yamashita, Youichi Saitoh,Toshiki Yoshimine
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Journal Title
Journal of Neurosurgery
Volume: In Press
Related Report
Peer Reviewed
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[Journal Article] Low-frequency subthalamic nucleus stimulation in Parkinson's disease: a randomized clinical trial.2014
Author(s)
Khoo HM, Kishima H, Hosomi K, Maruo T, Tani N, Oshino S, Shimokawa T, Yokoe M, Mochizuki H, Saitoh Y, Yoshimine T.
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Journal Title
Mov Disord.
Volume: 29(2)
Issue: 2
Pages: 2270-4
DOI
Related Report
Peer Reviewed
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[Journal Article] Which is the Most Appropriate Disconnection Surgery for Refractory Epilepsy in Childhood?2013
Author(s)
Kishima H, Oshoni S, Tani N, Maruo T, Morris S, Khoo HM, Yanagisawa T, Shimono K, Okinaga T, Hirata M, Kato A, Yoshimine T.
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Journal Title
Neurologia medico-chirurgica
Volume: 53
Issue: 11
Pages: 814-820
DOI
NAID
ISSN
0470-8105, 1349-8029
Related Report
Peer Reviewed
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[Presentation] Frameless image-guided stereotactic implantation of depth electrodes via craniotomy for pharmacoresistant epilepsy2014
Author(s)
Khoo HM, Kishima H, Oshino S, Tani N, Maruo T, Yanagisawa T, Edagawa K, Inoue Y, Hirata M, Yoshimine T
Organizer
2014 Annual Meeting of the American Epilepsy Society
Place of Presentation
Seattle, USA
Year and Date
2014-12-05 – 2014-12-09
Related Report
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[Presentation] Frameless image-guided stereotactic implantation of depth electrodes via craniotomy for pharmacoresistant epilepsy2014
Author(s)
Khoo HM, Kishima H, Oshino S, Tani N, Maruo T, Yanagisawa T, Edagawa K, Inoue Y, Hirata M, Yoshimine T
Organizer
The 8th Asian Epilepsy Surgery Congress
Place of Presentation
Tokyo,Japan
Year and Date
2014-10-04 – 2014-10-06
Related Report
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[Presentation] The efficacy of the study with intracranial electroencephalography in relation to epileptic pathology2014
Author(s)
Oshino S, Kishima H, Hirata M, Yanagisawa T, Edagawa K, Khoo HM, Inoue Y, Tani N, Kobayashi M, Yoshimine T
Organizer
The 8th Asian Epilepsy Surgery Congress
Place of Presentation
Tokyo,Japan
Year and Date
2014-10-04 – 2014-10-06
Related Report
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[Presentation] 脳深部刺激術の合併症
Author(s)
田中将貴、谷直樹、後藤恵、生塩之敬、吉峰俊樹
Organizer
日本脳神経外科学会第７２回学術総会
Place of Presentation
パシフィコ横浜（神奈川県）
Related Report
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[Presentation] 脳深部刺激術後の精神症状
Author(s)
田中将貴、谷直樹、後藤恵、生塩之敬、吉峰俊樹
Organizer
第５３回 日本定位・機能神経外科学会
Place of Presentation
大阪国際会議場（大阪）
Related Report
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