| Project/Area Number |
24791508
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Kochi University |
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Principal Investigator |
KAWANISHI Yu 高知大学, 教育研究部医療学系, 助教 (90527582)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | スピルリナ / 免疫療法 / 悪性グリオーマ / 悪性神経膠腫 |
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| Research Abstract |
I represented the first report of the suppressive effect of Spirulina complex polysaccharides (CPS) on glioma growth. Murine RSV-M glioma cells were implanted in C3H/HeN mice and TLR4-mutant C3H/HeJ mice. Growth of RSV-M glioma cells was severely suppressed in C3H/HeN mice, but not in C3H/HeJ mice, after treatment with Spirulina CPS. Spirulina CPS suppressed IL-17 production from serum of glioma-bearing C3H/HeN. Furthermore, in C3H/HeN mice, Spirulina CPS treatment suppressed growth of re-transplanted glioma, suggesting enhancement of the immune response by Spirulina CPS. Lower level of angiogenesis was observed in gliomas from Spirulina CPS-treated mice compared to those from saline- or E. coli LPS-treated mice. These results suggest that Spirulina CPS antagonizes glioma cell growth by down-regulating angiogenesis, in part, by regulating IL-17 production in C3H/HeN mice. Spirulina CPS may constitute a novel treatment for malignant glioma.
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