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Gene expression profiling of cerebral artery and search for biomarkers of cerebral vasospasm after subarachnoid hemorrhage

Research Project

Project/Area Number 24791510
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Cerebral neurosurgery
Research InstitutionKyushu University

Principal Investigator

KIKKAWA Yuichiro  九州大学, 大学病院, 助教 (80423515)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
KeywordsCerebral vasospasm / Subarachnoid hemorrhage / Microarray / Gene expression / CT angiography / マイクロアレイ / 脳血管攣縮 / くも膜下出血 / 脳底動脈
Research Abstract

Cerebral vasospasm is one of the most important cerebrovascular events following subarachnoid hemorrhage (SAH) and characterized by delayed and prolonged contraction of cerebral arteries, which may cause cerebral ischemia and lead to death or neurological deficits in patients with SAH. However, the molecular mechanisms which contribute to the development of vascular events including cerebral vasospasm remain to be elucidated. In this study, we investigated the time course of changes in the gene expression of cerebral artery using rabbit SAH model by using Agilent rabbit oligo DNA microarrays. Microarray analysis revealed that the number, magnitude of fold change, and gene expression pattern were most dynamically changed on day 3, whereas CT angiography revealed significant narrowing of basilar artery with a peak on day 5 after SAH.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (39 results)

All 2014 2013 2012 Other

All Journal Article (11 results) (of which Peer Reviewed: 5 results) Presentation (28 results) (of which Invited: 2 results)

  • [Journal Article] Gene Expression Profiling and Bioinformatic Analysis of Rabbit Basilar Artery after Experimental Subarachnoid Hemorrhage2014

    • Author(s)
      Matsuo S, Kikkawa Y, Hokama M, Kurogi R, Nakamizo A, Mizoguchi M, Sasaki T
    • Journal Title

      J Neurol Neurophysiol

      Volume: 5 Issue: 03 Pages: 1000201-1000201

    • DOI

      10.4172/2155-9562.1000201

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A Rabbit Cisterna Magna Double Injection Subarachnoid Hemorrhage Model2014

    • Author(s)
      Kikkawa Y
    • Journal Title

      Acta Neurochir Suppl

      Volume: in press

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Mechanism underlying Increased Vascular Smooth Muscle Contractility in the Rabbit Basilar Artery following Subarachnoid Hemorrhage2014

    • Author(s)
      Kikkawa Y, Kameda K, Matsuo S, Kurogi R, Nakamizo A, Mizoguchi M, Sasaki T
    • Journal Title

      Acta Neurochir Suppl

      Volume: in press

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Proposed Mechanism of Cerebral Vasospasm: Our Hypothesis and Current Topics2013

    • Author(s)
      Sasaki T
    • Journal Title

      Acta Neurochirurgica supplment

      Volume: 113 Pages: 53-56

    • DOI

      10.1007/978-3-7091-1192-5_12

    • ISBN
      9783709111918, 9783709111925
    • Related Report
      2013 Annual Research Report 2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Combined argatroban and anti-oxidative agents prevents increased vascular contractility to thrombin and other ligands after subarachnoid hemorrhage2012

    • Author(s)
      Kameda K, Kikkawa Y, Sasaki T, et al
    • Journal Title

      British Journal of Pharmacology

      Volume: 165(1) Issue: 1 Pages: 106-119

    • DOI

      10.1111/j.1476-5381.2011.01485.x

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Mechanisms Underlying Potentiation of Endothelin-1-induced Myofilament Ca^<2+> Sensitization after Subarachnoid Hemorrhage2012

    • Author(s)
      Kikkawa Y, Nakamizo A, Sasaki T, et al
    • Journal Title

      Journal of Cerebral Blood Flow and Metabolism

      Volume: 31 Issue: 2 Pages: 341-352

    • DOI

      10.1038/jcbfm.2011.132

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] 超高解像度256 列多列検出器型CT を用いたウサギくも膜下出血モデルにおける攣縮血管径の経時的評価2012

    • Author(s)
      吉川 雄一郎, 松尾 諭, 黒木 亮太, 森 恩, 中溝 玲, 吉本 幸司, 溝口 昌弘, 佐々木 富男
    • Journal Title

      脳血管攣縮(脳卒中の外科)

      Volume: 28(40)(suppl) Pages: 25-27

    • Related Report
      2013 Final Research Report
  • [Journal Article] 超高解像度256列多列検出器型CTを用いたウサギくも膜下出血モデルにおける攣縮血管径の経時的評価2012

    • Author(s)
      吉川雄一郎 ほか
    • Journal Title

      脳血管攣縮

      Volume: 28 Pages: 25-27

    • Related Report
      2012 Research-status Report
  • [Journal Article] Gene Expression Profiling and Bioinformatic Analysis of Rabbit Basilar Artery after Experimental Subarachnoid Hemorrhage

    • Author(s)
      Matsuo S, Kikkawa Y, Hokama M, Kurogi R, Nakamizo A, Mizoguchi M, Sasaki T
    • Journal Title

      J Neurol Neurophysiol

      Volume: (in press)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] A Rabbit Cisterna Magna Double Injection Subarachnoid Hemorrhage Model

    • Author(s)
      Kikkawa Y
    • Journal Title

      Acta Neurochir Suppl

      Volume: (in press)

    • Related Report
      2013 Final Research Report
  • [Journal Article] Mechanism underlying Increased Vascular Smooth Muscle Contractility in the Rabbit Basilar Artery following Subarachnoid Hemorrhage

    • Author(s)
      Kikkawa Y, Kameda K, Matsuo S, Kurogi R, Nakamizo A, Mizoguchi M, Sasaki T
    • Journal Title

      Acta Neurochir Suppl

      Volume: (in press)

    • Related Report
      2013 Final Research Report
  • [Presentation] ウサギくも膜下出血モデルにおけるultra-high resolution CT を用いた脳血管攣縮と微小脳循環評価の試み2014

    • Author(s)
      吉川雄一郎, 松尾 諭, 黒木亮太, 中溝 玲, 溝口昌弘, 飯原弘二, 佐々木富男
    • Organizer
      第30回スパズムシンポジウム
    • Place of Presentation
      大阪国際会議場(大阪)
    • Year and Date
      2014-03-13
    • Related Report
      2013 Final Research Report
  • [Presentation] ウサギくも膜下出血モデルにおけるrelaxinの発現とその役割2014

    • Author(s)
      松尾 諭, 吉川雄一郎, 黒木 亮太中溝 玲, 溝口 昌弘, 飯原 弘二, 佐々木 富男
    • Organizer
      第30回スパズムシンポジウム
    • Place of Presentation
      大阪国際会議場(大阪)
    • Year and Date
      2014-03-13
    • Related Report
      2013 Final Research Report
  • [Presentation] ウサギくも膜下出血モデルの脳血管における細胞外マトリックス代謝調節メカニズムとその役割に関する検討2014

    • Author(s)
      黒木 亮太, 吉川雄一郎, 松尾 諭中溝 玲, 溝口 昌弘, 飯原 弘二, 佐々木 富男
    • Organizer
      第30回スパズムシンポジウム
    • Place of Presentation
      大阪国際会議場(大阪)
    • Year and Date
      2014-03-13
    • Related Report
      2013 Final Research Report
  • [Presentation] ウサギくも膜下出血モデル脳底動脈におけるrelaxin の発現とその役割2013

    • Author(s)
      松尾 諭, 吉川雄一郎, 黒木 亮太, 中溝 玲, 吉本 幸司, 溝口 昌弘, 佐々木 富男
    • Organizer
      第72回日本脳神経外科学会総会
    • Place of Presentation
      パシフィコ横浜(神奈川)
    • Year and Date
      2013-10-16
    • Related Report
      2013 Final Research Report
  • [Presentation] ウサギくも膜下出血モデル脳底動脈における細胞外マトリックスのリモデリングに関わるタンパク質の発現変動とその役割2013

    • Author(s)
      黒木 亮太, 吉川雄一郎, 松尾 諭, 中溝 玲, 吉本 幸司, 溝口 昌弘, 佐々木 富男
    • Organizer
      第72回日本脳神経外科学会総会
    • Place of Presentation
      パシフィコ横浜(神奈川)
    • Year and Date
      2013-10-16
    • Related Report
      2013 Final Research Report
  • [Presentation] Rabbit cisterna magna double injection model2013

    • Author(s)
      Yuichiro Kikkawa
    • Organizer
      12th International Conference on Neurovascular Events after SAH,Vasospasm2013
    • Place of Presentation
      Lucerne (Switzerland)
    • Year and Date
      2013-07-11
    • Related Report
      2013 Final Research Report
  • [Presentation] Impaired feedback inhibition of receptor activity contributes to increased vascular contractility after subarachnoid hemorrhag2013

    • Author(s)
      Yuichiro Kikkawa, Katsuharu Kameda, Satoshi Matsuo, Ryota Kurogi, Akira Nakamizo, Tomio Sasaki
    • Organizer
      12th International Conference on Neurovascular Events after SAH, Vasospasm2013
    • Place of Presentation
      Lucerne (Switzerland)
    • Year and Date
      2013-07-10
    • Related Report
      2013 Final Research Report
  • [Presentation] Expression of relaxin and RFXP-1 in the rabbit basilar artery after experimental subarachnoid hemorrhage2013

    • Author(s)
      Satoshi Matsuo, Yuichiro Kikkawa, Ryota Kurogi, Akira Nakamizo, Tomio Sasaki
    • Organizer
      12th International Conference on Neurovascular Events after SAH, Vasospasm2013
    • Place of Presentation
      Lucerne (Switzerland)
    • Year and Date
      2013-07-10
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] Expression of TIMP-1 and MMP-9 in the rabbit basilar artery after subarachnoid hemorrhage2013

    • Author(s)
      Ryota Kurogi, Yuichiro Kikkawa, Satoshi Matsuo, Akira Nakamizo, Tomio Sasaki
    • Organizer
      12th International Conference on Neurovascular Events after SAH, Vasospasm2013
    • Place of Presentation
      Lucerne (Switzerland)
    • Year and Date
      2013-07-10
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] 関連文献レビュー(基礎編)2013

    • Author(s)
      吉川雄一郎
    • Organizer
      第29回スパズムシンポジウム
    • Place of Presentation
      グランドプリンスホテル新品川(東京)
    • Year and Date
      2013-03-20
    • Related Report
      2013 Final Research Report
  • [Presentation] ウサギくも膜下出血後脳血管におけるrelaxin の発現とその意義2013

    • Author(s)
      松尾諭, 吉川雄一郎, 黒木亮太, 中溝玲, 吉本幸司, 溝口昌弘, 佐々木富男
    • Organizer
      第29回スパズムシンポジウム
    • Place of Presentation
      グランドプリンスホテル新品川(東京)
    • Year and Date
      2013-03-20
    • Related Report
      2013 Final Research Report
  • [Presentation] くも膜下出血後ウサギ脳血管における細胞外基質関連タンパク質の発現とその役割2013

    • Author(s)
      黒木亮太, 吉川雄一郎, 松尾諭, 中溝玲, 吉本幸司, 溝口昌弘, 佐々木富男
    • Organizer
      第29回スパズムシンポジウム
    • Place of Presentation
      グランドプリンスホテル新品川(東京)
    • Year and Date
      2013-03-20
    • Related Report
      2013 Final Research Report
  • [Presentation] 関連論文レビュー(基礎編)2013

    • Author(s)
      吉川雄一郎
    • Organizer
      第29回スパズム・シンポジウム
    • Place of Presentation
      新高輪グランドプリンスホテル(品川)
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] 超高解像度256 列MDCT を用いたウサギくも膜下出血モデルの脳血管攣縮評価2012

    • Author(s)
      吉川雄一郎, 松尾諭, 黒木亮太, 森恩, 中溝玲, 吉本幸司, 溝口昌弘, 佐々木富男
    • Organizer
      第71回日本脳神経外科学会総会
    • Place of Presentation
      大阪国際会議場(大阪)
    • Year and Date
      2012-10-14
    • Related Report
      2013 Final Research Report
  • [Presentation] ウサギ SAH モデルの脳血管における遺伝子発現の経時的変化とその意義2012

    • Author(s)
      松尾諭, 吉川雄一郎, 外間政朗, 黒木亮太, 中溝玲, 吉本幸司, 溝口昌弘, 佐々木富男
    • Organizer
      第71回日本脳神経外科学会総会
    • Place of Presentation
      大阪国際会議場(大阪)
    • Year and Date
      2012-10-14
    • Related Report
      2013 Final Research Report
  • [Presentation] 超高解像度256 列MDCT を用いたウサギくも膜下出血モデルの攣縮血管径評価2012

    • Author(s)
      吉川雄一郎, 松尾諭, 森恩, 中溝玲, 吉本幸司, 溝口昌弘, 佐々木富男
    • Organizer
      第28回スパズムシンポジウム
    • Place of Presentation
      福岡国際会議場(福岡)
    • Year and Date
      2012-04-26
    • Related Report
      2013 Final Research Report
  • [Presentation] くも膜下出血後ウサギ脳血管における遺伝子発現プロファイリング2012

    • Author(s)
      松尾諭, 吉川雄一郎, 外間政朗, 中溝玲, 吉本幸司, 溝口昌弘, 佐々木富男
    • Organizer
      第28回スパズムシンポジウム
    • Place of Presentation
      福岡国際会議場(福岡)
    • Year and Date
      2012-04-26
    • Related Report
      2013 Final Research Report
  • [Presentation] 超高解像度256列MDCTを用いたウサギくも膜下出血モデルの攣縮血管径評価2012

    • Author(s)
      吉川雄一郎 ほか
    • Organizer
      第28回スパズム・シンポジウム
    • Place of Presentation
      福岡国際会議場(福岡)
    • Related Report
      2012 Research-status Report
  • [Presentation] くも膜下出血後ウサギ脳血管における遺伝子発現プロファイリング2012

    • Author(s)
      松尾諭、吉川雄一郎 ほか
    • Organizer
      第28回スパズム・シンポジウム
    • Place of Presentation
      福岡国際会議場(福岡)
    • Related Report
      2012 Research-status Report
  • [Presentation] 超高解像度256列MDCTを用いたウサギくも膜下出血モデルの脳血管攣縮評価2012

    • Author(s)
      吉川雄一郎 ほか
    • Organizer
      第71回日本脳神経外科学会総会
    • Place of Presentation
      大阪国際会議場(大阪)
    • Related Report
      2012 Research-status Report
  • [Presentation] ウサギSAHモデルの脳血管における発現遺伝子の経時的変化とその意義2012

    • Author(s)
      松尾諭、吉川雄一郎 ほか
    • Organizer
      第71回日本脳神経外科学会総会
    • Place of Presentation
      大阪国際会議場(大阪)
    • Related Report
      2012 Research-status Report
  • [Presentation] Rabbit cisterna magna double injection model

    • Author(s)
      Yuichiro Kikkawa
    • Organizer
      12th International Conference on Neurovascular Events after SAH, Vasospasm2013
    • Place of Presentation
      Lucerne (Switzerland)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Impaired feedback inhibition of receptor activity contributes to increased vascular contractility after subarachnoid hemorrhage

    • Author(s)
      Yuichiro Kikkawa, Katsuharu Kameda, Satoshi Matsuo, Ryota Kurogi, Akira Nakamizo, Tomio Sasaki
    • Organizer
      12th International Conference on Neurovascular Events after SAH, Vasospasm2013
    • Place of Presentation
      Lucerne (Switzerland)
    • Related Report
      2013 Annual Research Report
  • [Presentation] ウサギくも膜下出血モデル脳底動脈におけるrelaxinの発現とその役割

    • Author(s)
      松尾 諭、吉川 雄一郎、黒木 亮太、中溝 玲、吉本 幸司、 溝口 昌弘、佐々木 富男
    • Organizer
      第72回日本脳神経外科学会総会
    • Place of Presentation
      パシフィコ横浜(神奈川)
    • Related Report
      2013 Annual Research Report
  • [Presentation] ウサギくも膜下出血モデル脳底動脈における細胞外マトリックスのリモデリングに関わるタンパク質の発現変動とその役割

    • Author(s)
      黒木 亮太、吉川 雄一郎、松尾 諭、中溝 玲、吉本 幸司、溝口 昌弘、佐々木 富男
    • Organizer
      第72回日本脳神経外科学会総会
    • Place of Presentation
      パシフィコ横浜(神奈川)
    • Related Report
      2013 Annual Research Report
  • [Presentation] ウサギくも膜下出血モデルにおける ultra-high resolution CTを用いた脳血管攣縮と微小脳循環評価の試み

    • Author(s)
      吉川雄一郎、松尾 諭、黒木亮太、中溝 玲、溝口昌弘、飯原弘二、佐々木富男
    • Organizer
      第30回スパズムシンポジウム
    • Place of Presentation
      大阪国際会議場(大阪)
    • Related Report
      2013 Annual Research Report
  • [Presentation] ウサギくも膜下出血モデルにおけるrelaxinの発現とその役割

    • Author(s)
      松尾 諭、吉川 雄一郎、黒木 亮太、中溝 玲、溝口 昌弘、飯原 弘二、佐々木 富男
    • Organizer
      第30回スパズムシンポジウム
    • Place of Presentation
      大阪国際会議場(大阪)
    • Related Report
      2013 Annual Research Report
  • [Presentation] ウサギくも膜下出血モデルの脳血管における細胞外マトリックス代謝調節メカニズムとその役割に関する検討

    • Author(s)
      黒木 亮太、吉川 雄一郎、松尾 諭、中溝 玲、溝口 昌弘、飯原 弘二、佐々木 富男
    • Organizer
      第30回スパズムシンポジウム
    • Place of Presentation
      大阪国際会議場(大阪)
    • Related Report
      2013 Annual Research Report

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Published: 2013-05-31   Modified: 2019-07-29  

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