| Project/Area Number |
24791524
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthopaedic surgery
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| Research Institution | The University of Tokyo |
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Principal Investigator |
MIURA Shogo 東京大学, 医学部附属病院, 特任助教 (90529182)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | シグナル伝達 / 発生・分化 / 骨芽細胞 / 骨肉腫 / 薬理学 |
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| Research Abstract |
Assuming the therapy which suppresses proliferating osteosarcoma cells by converting from proliferative state to osteoblastic differentiate state, we have tried to elucidate the signalings which regulate osteoblastic differentiation. Previous studies have shown that beta-catenin signaling induced by Wnt molecules are critical, however, the relationship between numerous number of Wnt family molecules and their activating signalings is largely unclear. Thereby, for Wnt family molecules, the confrontation between the effects on an osteoblastic activity and an extent of the activity of 4 signalings known to function downstream was performed comprehensively. As a result, it has been elucidated that the extent of osteoblastic differentiation cannot be explained only by known signalings or known modes of signaling activation. Although the detailed analysis of this unknown regulations has still been ongoing, it is worthy of analysis with anticipating the discovery of new therapeutic targets.
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