Role of microRNA in fracture healing and its potentail application

• Project/Area Number: 24791544
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Orthopaedic surgery
• Research Institution: Kobe University
• Principal Investigator: LEE Sang Yang 神戸大学, 医学部附属病院, 特定助教 (40533732)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 骨折治癒 / microRNA / 骨再生 / 偽関節 / miRNA / 骨折 / 難治性骨折 / 創薬 / マイクロアレイ / PCR

Research Abstract

We for the first time showed microRNA expression patterns specific for fracture healing in rats. Our study revealed five microRNAs that remarkably increased and five microRNAs that remarkably decreased in the process of fracture healing. To characterize microRNA profiles in fracture healing is important for understanding the molecular mechanism for fracture healing. This study may provide new evidence for the clinical application of microRNA for enhancement of fracture healing.

Research Products

• [Presentation] Potential Role of MicroRN A during Fracture Healing (2014)
  • Author(s): Waki T, Lee SY, Niikura T, Iwakura T, Dogaki Y, Okumachi E, Takahara S, K urosaka M
  • Organizer: 2nd AOTra uma Asia Pacific Scientific Congress
  • Place of Presentation: Seoul, South Korea
• [Presentation] Potential Role of Micro RNA in fracture nonunion (2014)
  • Author(s): Waki T, Lee SY, Niikura T, Iwakura T, Dogaki Y, Okumachi E, Takahara S, Kurosaka M
  • Organizer: 2nd AOTrau ma Asia Pacific Scientific Congress
  • Place of Presentation: Seoul, South Korea
• [Presentation] 骨折治癒過程におけるmicroRNA発現の網羅的解析 (2014)
  • Author(s): 脇貴洋, 李相亮, 新倉隆宏, 岩倉崇, 奥町悦子, 高原俊介, 黒田良祐, 黒坂昌弘
  • Organizer: 第122回中部日本整形外科災害外科学会・学術集会
  • Place of Presentation: 岡山
• [Presentation] Potential Rol e of microRNA in Fracture Healing in Rats (2014)
  • Author(s): Waki T, Lee SY, Niikura T, Iwakura T, Dogaki Y, Okumachi E, Takahara S, Kuroda R, Kurosaka M
  • Organizer: 60th Annual Meeting of Orthop aedic Research Society
  • Place of Presentation: New Orleans, USA
• [Presentation] 骨折治癒過程におけるmicroRNA発現の網羅的解析 (2014)
  • Author(s): 脇貴洋, 李相亮, 新倉隆宏, 岩倉崇, 堂垣佳宏, 高原俊介, 黒田良祐, 黒坂昌弘
  • Organizer: 第13回日本再生医療学会総会
  • Place of Presentation: 京都
• [Presentation] 骨折治癒過程におけるmicroRNA発現の網羅的解析 (2014)
  • Author(s): 脇 貴洋、李 相亮、新倉 隆宏、岩倉 崇、堂垣 佳宏、高原 俊介、黒田 良祐、黒坂 昌弘
  • Organizer: 日本再生医療学会
  • Place of Presentation: 京都国際会館
• [Presentation] 骨折治癒過程におけるmicroRNA発現の網羅的解析 (2014)
  • Author(s): 脇貴洋、李相亮、新倉隆宏、岩倉崇、奥町悦子、高原俊介、黒田良祐、黒坂昌弘
  • Organizer: 中部日本整形外科災害外科学会
  • Place of Presentation: 岡山コンベンションセンター
• [Presentation] Potential Role of microRNA in Fracture Healing in Rats (2014)
  • Author(s): Takahiro Waki ,Sang Yang Lee, Takahiro Niikura, Takashi Iwakura, Yoshihiro Dogaki, Etsuko Okumachi, Syunsuke Takahara, Masahiro Kurosaka
  • Organizer: Orthopaedic Research Society
  • Place of Presentation: Hyatt Regency New Orelans, USA
• [Presentation] ラット偽関節モデルにおけるmicroRNA発現の網羅的解析 (2013)
  • Author(s): 脇貴洋, 李相亮, 新倉隆宏, 古賀敬章, 堂垣佳宏, 奥町悦子, 黒坂昌弘
  • Organizer: 第28回日本整形外科学会基礎学術集会
  • Place of Presentation: 千葉
• [Presentation] Profiling microRNA expres sion in fracture nonunion (2013)
  • Author(s): Waki T, Lee SY, Niikura T, Iwakura T, Dogaki Y, Okumachi E, Kuroda R, K urosaka M
  • Organizer: 8th Combi ned Meeting of Orthopaedic Research Society
  • Place of Presentation: Venice, Italy
• [Presentation] 偽関節形成過程におけるmicroRNA発現の網羅的解析 (2013)
  • Author(s): 脇貴洋, 李相亮, 新倉隆宏, 岩倉崇, 黒田良祐, 黒坂昌弘
  • Organizer: 第121回中部日本整形外科災害外科学会・学術集会
  • Place of Presentation: 名古屋
• [Presentation] Pot ential Role of microRNA in nonunion formation in Rat (2013)
  • Author(s): Waki T, Lee SY, Niikura T, Koga T, D ogaki Y, Okumachi E, Kurosaka M
  • Organizer: 59th Annual Meetin g of Orthopaedic Research Society
  • Place of Presentation: San Antonio, USA
• [Presentation] ラット偽関節モデルにおけるmicroRNA発現の網羅的解析 (2013)
  • Author(s): 脇 貴洋、李 相亮、新倉 隆宏、岩倉 崇、黒田 良祐、黒坂 昌弘
  • Organizer: 中部日本整形外科災害外科学会
  • Place of Presentation: 名古屋国際会議場
• [Presentation] ラット偽関節モデルにおけるmicroRNA発現の網羅的解析 (2013)
  • Author(s): 脇 貴洋、李 相亮、新倉 隆宏、古賀 敬章、堂垣 佳宏、奥町 悦子、黒坂 昌弘
  • Organizer: 日本整形外科学会基礎学術集会
  • Place of Presentation: 幕張メッセ
• [Presentation] Profiling microRNA expression in fracture nonunion (2013)
  • Author(s): Takahiro Waki, Sang Yang Lee, Takahiro Niikura, Takashi Iwakura, Yoshihiro Dogaki, Etsuko Okumachi, Ryosuke Kuroda, Masahiro Kurosaka
  • Organizer: Combined Meeting of Orthopaedic Research Societies
  • Place of Presentation: Congress Center of San Servolo, Venice
• [Presentation] Potential Role of microRNA in nonunion in Rat. (2013)
  • Author(s): 脇 貴洋
  • Organizer: The 59th Annual Meeting of Orthopaedic Research Society.
  • Place of Presentation: San Antonio, TX, USA