Antitumor Effect of Zoledronic Acid-Loaded Phosphorylated Pullulan on Bone Metastasis Model of Mice.

• Project/Area Number: 24791548
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Orthopaedic surgery
• Research Institution: Okayama University
• Principal Investigator: TAKEDA Ken 岡山大学, 医歯(薬)学総合研究科, 助教 (70614923)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: がん骨転移 / ゾレドロン酸 / ビスフォスフォネート / ビスホスホネート / 転移性骨腫瘍

Research Abstract

We analyzed in vitro and in vivo antitumor effect of the mixture of zoledronic acid and phosphorylated pullulan for human breast cancer cell line. The elution of zoledronic acid released from phosphorylated pullulan exhibited antitumor effect. Phosphorylated pullulan exhibited a drug release property for zoledronic acid. The local administration of the mixture of the mixture of zoledronic acid and phosphorylated pullulan into the metastatic bone tumor model of nude mice exhibited antitumor effect. Furthermore, bone formation was observed around the mixture.

Research Products

• [Presentation] Surgical treatment of Giant Cell Tumor of Bone in extremity (2013)
  • Author(s): Ken Takeda
  • Organizer: International Society of Limb salvage 17th General Meeting
  • Place of Presentation: ボローニャ(イタリア)
• [Presentation] Surgical treatment of Giant Cell Tumor of Bone in extremity. (2013)
  • Author(s): Ken Takeda
  • Organizer: International Society of Limb salvage 17th General Meeting
  • Place of Presentation: ボローニャ（イタリア）