Role of heparan sulfate endosulfatase for chondrogenesis and osteoarthritis therapy
| Project/Area Number |
24791571
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Osaka Medical College |
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Principal Investigator |
OTSUKI Shuhei 大阪医科大学, 医学部, 助教 (20589840)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 軟骨再生 / 変形性関節症 / ヘパラン硫酸 / ヘパラン硫酸脱硫酸酵素 / 軟骨 / MMP-13 / Sulf-1 |
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| Outline of Final Research Achievements |
chondrocyte clusters adjacent to severe cartilage degeneration have specific characteristics, with progenitor and proliferative potential. Intra-articular injection of Sulf-1 suppressed OA progression with MMP-13 down-regulation. Sulfs may have the potential of the novel OA therapy.
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Report
(4 results)
Research Products
(2 results)
