Role of heparan sulfate endosulfatase for chondrogenesis and osteoarthritis therapy

Research Project

Project/Area Number	24791571
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Orthopaedic surgery
Research Institution	Osaka Medical College
Principal Investigator	OTSUKI Shuhei 大阪医科大学, 医学部, 助教 (20589840)
Project Period (FY)	2012-04-01 – 2015-03-31
Project Status	Completed (Fiscal Year 2014)
Budget Amount *help	¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000) Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords	軟骨再生 / 変形性関節症 / ヘパラン硫酸 / ヘパラン硫酸脱硫酸酵素 / 軟骨 / MMP-13 / Sulf-1
Outline of Final Research Achievements	chondrocyte clusters adjacent to severe cartilage degeneration have specific characteristics, with progenitor and proliferative potential. Intra-articular injection of Sulf-1 suppressed OA progression with MMP-13 down-regulation. Sulfs may have the potential of the novel OA therapy.

Report

(4 results)