The identification of a molecular biological marker for spinal microglia reflecting postoperative pain

• Project/Area Number: 24791578
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: Gunma University
• Principal Investigator: MIEDA RIE 群馬大学, 医学部附属病院, 助教 (10400772)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 術後痛 / 脊髄マイクログリア

Outline of Final Research Achievements

To suppress the postoperative pain is one of the most important medical issues. Although upregulation of microglia in the spinal cord contributes to mechanical hypersensitivity after paw incision in rats, a specific molecular biological marker for spinal microglia reflecting postoperative pain is not identified. There are several molecular biological markers that reflects the activation of spinal microglia. Using postoperative pain rat model, the purpose of this study is to evaluate a correlation between those markers and postoperative pain.
I finished 80% of this study right now. Therefore, I will do my best to continue and complete this study.