| Project/Area Number |
24791600
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Nagasaki University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 強心薬 / 心筋梗塞サイズ縮小 / ポストコンディショニング / 心筋梗塞サイズ / 心筋保護効果 / レボシメンダン / ミルリノン / プロポフォール / ミトコンドリアATP感受性カリウムチャネル / 薬理学的ポストコンディショニング / プレコンディショニング |
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| Outline of Final Research Achievements |
We investigated the mechanism of cardioprotection associated with two inotropics, milrinone:MIL, a phosphodiesterase type 3 inhibitor, and levosimendan:LEV, a calcium sensitizer. A selective cyclooxygenase-2 inhibitor abolished LEV-induced cardioprotection(postconditioning). Now we try to clarify the activation of cyclooxygenase-2 protein in the cardioprotection with Westernblotting. Preischemic administration of MIL or LEV have showed tendency to decrease the myocardial infarct size, but not significant. Propofol(the Group of propofol+MIL or propofol+LEV) also have showed tendency to increase the myocardial infarct size compared with the Group of MIL or LEV(preischemic administration: i.e. preconditioning), but not significant.
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