Investigation of antimicrobial administration based on PK-PD using in vivo model of urinary tract infection due to drug-resistant Echerichia coli
| Project/Area Number |
24791651
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Urology
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| Research Institution | Okayama University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 尿路感染症 / 大腸菌 / 薬剤耐性 / ESBL産生菌 / 抗菌薬 / 治療法 / 薬物動態／薬力学 / マウス感染モデル / ESBL産生 / マウス尿路感染症モデル / MLST解析 |
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| Outline of Final Research Achievements |
In clinical study, characterization of clinical isolates of Escherichia coli (E. coli) isolated from urinary tract infection; development of culture medium in which drug-resistant E. coli isolates could be selectively cultured; investigation of administration duration of antimicrobials against uncomplicated cystitis; evaluation of penetration of various antimicrobials to human epididymis tissue, were completely performed.
In basic research, analysis of bacterial gene related with drug resistance; construction of mice model of urinary tract infection; evaluation of administration manner of antimicrobials using the model, were performed. However, effective dose and duration of antimicrobial treatment against biofilms in urinary tract could not be clarified.
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Report
(5 results)
Research Products
(25 results)
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[Presentation] Epidemiology of fluoroquinolone-insusceptible/Extended-Spectrum-Beta-Lactamases-producing Escherichia coli colonizing in Japanese male rectum2015
Author(s)
Koichiro Wada, Takuya Sadahira, Masumi Yamamoto, Ritsuko Mitsuhata, Motoo Araki, Ayano Ishii, Shinya Uehara, Toyohiko Watanabe, Yasutomo Nasu, Hiromi Kumon
Organizer
ICAAC/ICC (The Interscience Conference on Antimicrobial Agents and Chemotherapy/International Congress of Chemotherapy and Infection) 2015 meeting
Place of Presentation
San Diego, USA
Year and Date
2015-09-17
Related Report
Int'l Joint Research
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