An exploratory investigation of the biomarkers for senescence and arteriosclerosis in renal transplant donors and recipients
| Project/Area Number |
24791653
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Urology
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| Research Institution | Kagawa University |
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Principal Investigator |
SOFUE Tadashi 香川大学, 医学部附属病院, 助教 (80452671)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 生体腎移植 / マージナルドナー / 高血圧 / 老化 / 再発性腎炎 / 細胞老化 |
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| Outline of Final Research Achievements |
The level of senescence markers P16INK4A and SA-β-GAL in the donated kidney differed between living-kidney donors without proteinuria and kidney dysfunction when patients were classified by the age and presence of hypertension. Therefore, the quality of kidneys from donors based on the criteria of the Amsterdam forum was not uniform. The level of urinary albumin excretion was partially associated with that of senescence markers in the donated kidney.
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Report
(4 results)
Research Products
(67 results)
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[Journal Article] The efficacy and safety of febuxostat in the treatment of hyperuricemia in stable kidney transplant recipients.2014
Author(s)
Sofue T, Inui M, Hara T, Nishijima Y, Moriwaki K, Hayashida Y, Ueda N, Nishiyama A, Kakehi Y, Kohno M.
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Journal Title
Drug Design, Development and Therapy
Volume: 8
Pages: 245-253
DOI
Related Report
Peer Reviewed
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[Journal Article] Excess fluid distribution affects tacrolimus absorption in peritoneal dialysis patients2013
Author(s)
Sofue T, Inui M, Kiyomoto H, Moriwaki K, Hara T, Yamaguchi K, Fukuoka N, Banno K, Nishiyama A, Kakehi Y, Kohno M.
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Journal Title
Clinical and Experimental Nephrology
Volume: 17
Issue: 5
Pages: 743-749
DOI
Related Report
Peer Reviewed
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[Journal Article] Limited Sampling Strategy for the Estimation of Mycophenolic Acid Area under the Concentration–Time Curve Treated in Japanese Living-Related Renal Transplant Recipients with Concomitant Extended-Release Tacrolimus2013
Author(s)
Yamaguchi K, Fukuoka N, Kimura S, Watanabe M, Tani K, Tanaka H, Sofue T, Kosaka S, Inui M, Kakehi Y, Houchi H.
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Journal Title
Biological and Pharmaceutical Bulletin
Volume: 36
Issue: 6
Pages: 1036-1039
DOI
NAID
ISSN
0918-6158, 1347-5215
Related Report
Peer Reviewed
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[Journal Article] Latent IgA deposition from donor kidneys does not affect transplant prognosis, irrespective of mesangial expansion.2013
Author(s)
Sofue T, Inui M, Hara T, Moritoki M, Nishioka S, Nishijima Y, Moriwaki K, Hayashida Y, Ueda N, Kushida Y, Haba R, Nishiyama A, Kakehi Y, Kohno M.
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Journal Title
Clinical Transplantaion
Volume: 27
Issue: s26
Pages: 14-21
DOI
Related Report
Peer Reviewed
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[Journal Article] Pre-existing arteriosclerotic intimal thickening in living-donor kidneys reflects allograft function.2012
Author(s)
Sofue T, Inui M, Kiyomoto H, Moritoki M, Nishioka S, Nishijima Y, Moriwaki K, Hara T, Kushida Y, Haba R, Yoda T, Hirao T, Kakehi Y, Nishiyama A, Kohno M.
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Journal Title
American Journal of Nephrology
Volume: 36
Issue: 2
Pages: 127-135
DOI
Related Report
Peer Reviewed
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