The role of GPCR signaling in the progression of gynecological cancer
| Project/Area Number |
24791709
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Kyushu University |
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Principal Investigator |
YAGI Hiroshi 九州大学, 医学(系)研究科(研究院), 助教 (70623552)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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|---|
| Keywords | シグナル伝達 / 転移 / 癌 / 浸潤 |
|---|
| Research Abstract |
The GEP oncogene, members of the Ga12 family of heterotrimeric G proteins (Ga12/13), is involved in the progression of human cancers including breast and prostate. This study is focused on evaluating the role of GEP oncogene in human gynecological cancer progression.
Expression levels of Ga12/13 in human ovarian cancer tissues were elevated compared to those in normal ovarian tissues. In human cervical cancer cell lines, activation of SDF-1/CXCR4/Gai/Rac signaling pathway induced migration in vitro. In addition, SDF-1/CXCR4/Gai signaling pathway upregulated VEGF-C expression through p38 activation. Increased expression of GEP oncogene, Ga12/13, can result in enhanced signaling downstream of CXCR4, thereby influencing cell migration of ovarian cancer.
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Report
(3 results)
Research Products
(15 results)
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[Journal Article] PDZ-RhoGEF and LARG are essential for embryonic development and provide a link between thrombin and LPA receptors and Rho activation2013
Author(s)
Milelis CM, Palmby TR, Simaan M, Li W, Szabo R, Lyons R, Martin D, Yagi H, Fukuhara S, Chikumi H, Galisteo R, Mukouyama YS, Bugge TH, Gutkind JS
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Journal Title
J Biol Chem
Volume: 288(17)
Pages: 12232-43
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[Journal Article] PDZ-RhoGEF and LARG are essential for embryo development, and provide a link between thrombin and LPA receptors and Rho activation2013
Author(s)
Mikelis CM, Palmby TR, Simaan M, Li W, Szabo R, Lyons R, Martin D, Yagi H, Fukuhara S, Chikumi H, Galisteo R, Mukouyama Y, Bugge TH, Gutkind JS
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Journal Title
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Peer Reviewed
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[Presentation] 3mm以内の頸部間質浸潤に留まる子宮頸部腺癌 Ib1 期の術式は単純子宮全摘出術で十分か2012
Author(s)
矢幡秀昭, 麻生佳愛, 八木裕史, 井上貴史, 兼城英輔, 河野善明, 奥川馨, 園田顕三, 加来恒壽, 小林裕明, 和氣徳夫
Organizer
日本産科婦人科学会 第64回学術講演会
Place of Presentation
神戸市
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