Autophagy regulates galectin-4 expression in the rat trophoblast cell line and affects its differentaiton
| Project/Area Number |
24791726
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Kanazawa Medical University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | Galectin-４ / Autophagy / MMP / Ｉnvasive trophoblast / Ｐｌａｃｅｎｔａ / Galectin-4 / Invesive trophoblast / Placenta / ガレクチン / オートファジー / 免疫寛容 / 胎盤形態形成 |
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| Research Abstract |
This study aimed to investigate the expression of Gal4 in placentation. We utilized Rcho-1 cells derived from rat placenta and this cell line has been well established as a model system for trophoblast differentiation. The expression of Gal4 was revealed to be lower in differentiated Rcho-1 cells than that in proliferative cells. Of interest, overexpression of Gal4 during Rcho-1 differentiation resulted in moderate reduction of both cell mobility and cell enlargement. Notably, immunohistochemical analysis showed that Gal4 is preferentially located in the maternal-fetal zone of rat placenta, indicating that Gal4 would negatively regulate differentiation of Rcho-1 cells and/or limit their invasive property.
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Report
(3 results)
Research Products
(18 results)
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[Journal Article] Expression pattern of Galectin 4 in rat placentation2012
Author(s)
Arikawa T, Simamura E, Shimada H, Nishi N, Tatsuno T, Ishigaki Y, Tomosugi naohisa, Yamahiro C, Hata T, Takegami T, Nakamura T, Mogami H, Yamaguchi K, Otani H, Hatta T, and Shoji H
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Journal Title
Placenta (Short Communication)
Volume: 33(10)
Pages: 885-7
Related Report
Peer Reviewed
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[Journal Article] Expression pattern of Galectin 4in rat placentation.2012
Author(s)
Arikawa T,Simamura E,Shimada H,NishiN,TatsunoT,IshigakiY,TomosugiN,YamashiroC,HataT,TakegamiT,MogamiH,YamaguchiK,NakamuraT,OtaniH,HattaT,ShojiH.
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Journal Title
Placenta
Volume: 33
Issue: 10
Pages: 885-887
DOI
Related Report
Peer Reviewed
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