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Autophagy regulates galectin-4 expression in the rat trophoblast cell line and affects its differentaiton

Research Project

Project/Area Number 24791726
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Obstetrics and gynecology
Research InstitutionKanazawa Medical University

Principal Investigator

ARIKAWA Tomohiro  金沢医科大学, 一般教育機構, 講師 (70452670)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
KeywordsGalectin-4 / Autophagy / MMP / Invasive trophoblast / Placenta / Galectin-4 / Invesive trophoblast / Placenta / ガレクチン / オートファジー / 免疫寛容 / 胎盤形態形成
Research Abstract

This study aimed to investigate the expression of Gal4 in placentation. We utilized Rcho-1 cells derived from rat placenta and this cell line has been well established as a model system for trophoblast differentiation. The expression of Gal4 was revealed to be lower in differentiated Rcho-1 cells than that in proliferative cells. Of interest, overexpression of Gal4 during Rcho-1 differentiation resulted in moderate reduction of both cell mobility and cell enlargement. Notably, immunohistochemical analysis showed that Gal4 is preferentially located in the maternal-fetal zone of rat placenta, indicating that Gal4 would negatively regulate differentiation of Rcho-1 cells and/or limit their invasive property.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (18 results)

All 2014 2013 2012

All Journal Article (9 results) (of which Peer Reviewed: 8 results) Presentation (8 results) Book (1 results)

  • [Journal Article] T cells control innate hyperinflammation in LPS endotoxemia by downregulating macrophage TNF production via IRAK-1-mediated IL-10 expression2014

    • Author(s)
      Inoue M, Arikawa T, Chen YH, Moriwaki Y, Price M, Brown M, Perfect JR, Shinohara ML
    • Journal Title

      Proceedings of National Academy of Sciences of the United States of America

      Volume: (in press)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Significance of sugar chain recognition by galectins and its involvement in disease-associated glycosylation2014

    • Author(s)
      Arikawa T, Simamura E, Shimada H, Nakamura T, Hatta T, and Shoji H
    • Journal Title

      Congenital Anomalies

      Volume: (in press)

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of influenza A infection by galectin-92013

    • Author(s)
      Hattori T, Arikawa T, Fujioka Y, Maruyama J, Nakayama Y, Ohba Y, Niki T, Miyazaki T, Hirashima M, and Kida H
    • Journal Title

      Japanese Journal of Veterinary Research

      Volume: 61(1&2) Pages: 5-18

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 「ガレクチンによる糖鎖認識と免疫における意義」(An emerging role of sugar chain recognition by Galectins in immunity)2013

    • Author(s)
      有川智博, 東海林博樹, 平島光臣
    • Journal Title

      臨床化学

      Volume: 42 (1) Pages: 36-43

    • Related Report
      2013 Final Research Report
  • [Journal Article] Galectin-9 signaling prolongs survival in murine lung-cancer by inducing macrophages to differentiate into plasmacytoid dendritic cell-like macrophages2012

    • Author(s)
      Kadowaki T, Arikawa T, Shinonaga R, Oomizu S, Inagawa H, Soma G, Niki T, Hirashima M
    • Journal Title

      Clinical Immunology

      Volume: 142(3) Pages: 296-307

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Galectin-9 suppresses Th17 cell development in an IL-2-dependent but Tim-3-independent manner2012

    • Author(s)
      Oomizu S, Arikawa T, Niki T, Kadowaki T, Ueno M, Nishi N, Yamauchi A, and Hirashima M
    • Journal Title

      Cinical Immunology

      Volume: 143(1) Pages: 51-8

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expression pattern of Galectin 4 in rat placentation2012

    • Author(s)
      Arikawa T, Simamura E, Shimada H, Nishi N, Tatsuno T, Ishigaki Y, Tomosugi naohisa, Yamahiro C, Hata T, Takegami T, Nakamura T, Mogami H, Yamaguchi K, Otani H, Hatta T, and Shoji H
    • Journal Title

      Placenta (Short Communication)

      Volume: 33(10) Pages: 885-7

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cell surface galectin-9 expressing Th cells regulate Th17 and Foxp3+ Treg development by secreting galectin-92012

    • Author(s)
      Oomizu S, Arikawa T, Niki T, Kadowaki T, Ueno M, Nishi N, Yamauchi A, and Hirashima M.
    • Journal Title

      PLoS ONE

      Volume: 7(11)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expression pattern of Galectin 4in rat placentation.2012

    • Author(s)
      Arikawa T,Simamura E,Shimada H,NishiN,TatsunoT,IshigakiY,TomosugiN,YamashiroC,HataT,TakegamiT,MogamiH,YamaguchiK,NakamuraT,OtaniH,HattaT,ShojiH.
    • Journal Title

      Placenta

      Volume: 33 Issue: 10 Pages: 885-887

    • DOI

      10.1016/j.placenta.2012.07.013

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] Role of autophagy in rat trophoblast differentiation2013

    • Author(s)
      有川智博, 森尾佳苗, 島村英理子, 島田ひろき, 八田稔久, 東海林博樹
    • Organizer
      大36回 日本分子生物学会
    • Place of Presentation
      神戸(神戸国際会議場)
    • Related Report
      2013 Final Research Report
  • [Presentation] マウスγ ヘルペスウイルスはIL-27 依存的に肺炎症を惹起する2013

    • Author(s)
      渡部明子, 伊藤龍生, 有川智博, 榊原修平, 菊谷仁, 安居輝人, 義江修
    • Organizer
      第61回日本ウイルス学会学術集会
    • Place of Presentation
      神戸(神戸国際会議場)
    • Related Report
      2013 Final Research Report
  • [Presentation] Role of autophagy in rat trophoblast differentiation2013

    • Author(s)
      有川智博、森尾佳苗、,島村英理子、島田ひろき、八田稔久、東海林博樹
    • Organizer
      第36回 日本分子生物学会
    • Place of Presentation
      神戸ポートアイランド会議場
    • Related Report
      2013 Annual Research Report
  • [Presentation] Galectin-9 は細胞およびマウスにおけるインフルエンザA ウイルスの感染を抑制する.服部 ともえ2012

    • Author(s)
      丸山容一朗, 中山洋佑, 大場雄介, 仁木敏郎, 有川智博, 宮崎忠昭, 平島光臣, 喜田宏
    • Organizer
      第60回 日本ウイルス学会
    • Place of Presentation
      大阪(グランキューブ大阪)
    • Related Report
      2013 Final Research Report
  • [Presentation] Analysis of the Galectin 4 expression during trophoblast differentiation in rat placentation2012

    • Author(s)
      Arikawa T, Simamura E, Shimada H, Hatta T, Shoji H
    • Organizer
      国際胎盤学会
    • Place of Presentation
      広島(広島国際会議場)
    • Related Report
      2013 Final Research Report
  • [Presentation] Regulated expression of Galectin-4 in rat placentation2012

    • Author(s)
      Arikawa T, Simamura E, Shimada H, Otani H, Hatta T, and Shoji H
    • Organizer
      先天異常学会
    • Place of Presentation
      東京(東京女子医科大学)
    • Related Report
      2013 Final Research Report
  • [Presentation] Analysis of the Galectin 4 expression during trophoblast2012

    • Author(s)
      Tomohiro Arikawa
    • Organizer
      International Federation of Placenta Associations (IFPA)
    • Place of Presentation
      広島国際会議場
    • Related Report
      2012 Research-status Report
  • [Presentation] Reguated expression of Galectin 4 in rat placentation2012

    • Author(s)
      Tomohiro Arikawa
    • Organizer
      日本先天異常学会
    • Place of Presentation
      東京女子医科大学
    • Related Report
      2012 Research-status Report
  • [Book] ガレクチンによる糖鎖認識と免疫における意義2013

    • Author(s)
      有川智博
    • Total Pages
      8
    • Publisher
      臨床化学
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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