Elucidation of new ca2+-releasing molecule and its mechanism for infertility treatment
| Project/Area Number |
24791731
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Tokyo Medical University (2013-2015)
National Research Institute for Child Health and Development (2012) |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
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| Keywords | 受精 / Ca2+濃度上昇 / Citrate Synthase-like / 卵活性化 / Citrate synthase-like / クエン酸合成酵素 / Ca2+シグナル |
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| Outline of Final Research Achievements |
Fertilization is essential event for development. However, there is a lot of person who suffer from infertility. And so, I elucidated the factor which concern with fertilization in order to assist for infertility. As a result, citrate synthase-like was found as the new factor in mouse, the mammal model. Citrate synthase-like triggered Ca2+ increase in egg cytoplasm on introducing into the egg, and then was began the development of zygote. Also, enzyme activity in citrate synthase-like or interaction between other molecules and citrate synthase-like seems to be concerned with Ca2+ increase in egg cytoplasm. Furthermore, I am intend to clarify functions and mechanism of citrate synthase-like in fertilization.
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Report
(5 results)
Research Products
(3 results)
