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Studies of basic research about inner ear homeostasis of Meniere' s disease

Research Project

Project/Area Number 24791748
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Otorhinolaryngology
Research InstitutionThe University of Tokyo

Principal Investigator

EGAMI Naoya  東京大学, 医学部附属病院, 助教 (10505895)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywordsメニエール病 / 内リンパ水腫 / 抗利尿ホルモン / アクアポリン / メニエール病病態生理 / バゾプレッシン
Research Abstract

The purpose of this study was to clarify the underlying mechanism of vertiginous attacks in Ménière's disease (MD) with a new combined animal model. Our animal model induced severe endolymphatic hydrops (EH) in the cochlea and the saccule and showed episodes of balance disorder along with spontaneous nystagmus. These findings suggest that administration of vasopressin (VP) can exacerbate EH due to acute V2; VP type 2 receptor-mediated effects, and when combined with endolymphathic sac (ES) dysfunction can cause temporary vestibular abnormalities that are similar to the vertiginous attacks in patients with MD.Systemic or local application of VP type 2 receptor antagonistist; V2 antagonist (OPC-41061), an inhibitor of the VP-AQP2 reduced EH in the cochlea and the saccule.
These results suggest that VP-AQP2 system plays an important role in the pathogenesis of MD and an inhibitor of the VP-AQP2 system will be a promising drug in the treatment of MD.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (16 results)

All 2014 2013 2012

All Journal Article (8 results) (of which Peer Reviewed: 6 results) Presentation (8 results)

  • [Journal Article] Type 1 allergy-induced endolymphatic hydrops and the suppressive effect of h1-receptor antagonist (olopatadine hydrochloride).2014

    • Author(s)
      Egami N, Kakigi A, Takeda T, Takeda S, Nishioka R, Hyodo M, Yamasoba T
    • Journal Title

      Otol Neurotol

      Volume: 25 Issue: 3 Pages: e104-e109

    • DOI

      10.1097/mao.0000000000000195

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Morphological and functional changes in a new animal model of Ménière's disease2013

    • Author(s)
      Egami N, Kakigi A, Sakamoto T, Takeda T, Hyodo M, Yamasoba T
    • Journal Title

      Lab Invest

      Volume: 93(9) Pages: 1001-11

    • Related Report
      2013 Final Research Report
  • [Journal Article] Evaluation of the internal structure of normal and pathological guinea pig cochleae using optical coherence tomography2013

    • Author(s)
      Kakigi A, Takubo Y, Egami N, Kashio A, Ushio M, Sakamoto T, Yamashita S, Yamasoba T
    • Journal Title

      Audiol Neurootol

      Volume: 18 Pages: 335-343

    • Related Report
      2013 Final Research Report
  • [Journal Article] Morphological and functional changes in a new animal model of Ménière's disease.2013

    • Author(s)
      Egami N, Kakigi A, Sakamoto T, Takeda T, Hyodo M, Yamasoba T
    • Journal Title

      Lab Invest

      Volume: 93 Issue: 9 Pages: 1001-1011

    • DOI

      10.1038/labinvest.2013.91

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of the Internal Structure of Normal and Pathological Guinea Pig Cochleae Using Optical Coherence Tomography2013

    • Author(s)
      A. Kakigi, Y. Takubo, N. Egami, A. Kashio, M. Ushio, T. Sakamoto, S. Yamashita and T. Yamasoba
    • Journal Title

      Audiology and Neurotology

      Volume: Vol. 18 Issue: 5 Pages: 335-343

    • DOI

      10.1159/000354620

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The diagnostic value of vestibular evoked myogenic potentials in patients with Meniere’s disease.2013

    • Author(s)
      Egami N, Ushio M, Yamasoba T, Yamaguchi T, Murofush T, Iwasaki S
    • Journal Title

      J Vestib Res

      Volume: 23 Issue: 4-5 Pages: 249-257

    • DOI

      10.3233/ves-130484

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Localization of aquaporin1, 2, 3 and vasopressin type2 receptor in the mouse inner ear2012

    • Author(s)
      Takumida M
    • Journal Title

      Acta Otolaryngol

      Volume: 132 Pages: 807-813

    • DOI

      10.3109/00016489.2012.662718

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Type 1 allergy-induced endolymphatic hydrops and the suppressive effect of leukotriene receptor antagonist.2012

    • Author(s)
      Takeda T, Takeda S, Egami N, Kakigi A, Nishioka R, Yamasoba T.
    • Journal Title

      Otol Neurotol.

      Volume: 33(5) Issue: 5 Pages: 886-90

    • DOI

      10.1097/mao.0b013e3182565a27

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] The effects of vasopressin type 2 receptor antagonist (OPC-41061) on endolymphatic hydrops2014

    • Author(s)
      Egami N, Kakigi A, Takeda T, Yamasoba T
    • Organizer
      The Association for Research in Otolaryngology, 37th MidWinter Metting
    • Place of Presentation
      SanDiego, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] The effects of vasopressin type 2 receptor antagonist (OPC-41061) on endolymphatic hydrops2014

    • Author(s)
      Egami N, Kakigi A, Takeda T, Yamasoba T
    • Organizer
      Association for Research in Otolaryngology
    • Place of Presentation
      アメリカ合衆国(San Diego)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Morphological and functional changes in a new animal model for Meniere's disease2013

    • Author(s)
      Egami N, Kakigi A, Takeda T, Yamasoba T
    • Organizer
      The Association for Research in Otolaryngology, 36th MidWinter Metting
    • Place of Presentation
      Baltimore, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] Morphological and functional changes in a new animal model for Meniere’s disease2013

    • Author(s)
      Egami N, Kakigi A, Takeda T, Yamasoba T
    • Organizer
      Association for Research in Otolaryngology
    • Place of Presentation
      アメリカ合衆国(Baltimore)
    • Related Report
      2012 Research-status Report
  • [Presentation] メニエール病モデル動物におけるV2R 拮抗的阻害薬の内リンパ水腫軽減効果に関する検2012

    • Author(s)
      江上直也, 柿木章伸, 坂本幸士, 西岡利恵, 竹田泰三, 兵頭政光, 山岨達也
    • Organizer
      第113回日本耳鼻咽喉科学会総会・学術講演会
    • Place of Presentation
      新潟
    • Related Report
      2013 Final Research Report
  • [Presentation] メニエール病モデル動物におけるV2R 拮抗的阻害薬の効果に関する検討2012

    • Author(s)
      江上直也, 柿木章伸, 竹田泰三, 兵頭政光, 山岨達也
    • Organizer
      第71回日本めまい平衡医学会総会・学術講演会
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report
  • [Presentation] メニエール病モデル動物におけるV2R拮抗的阻害薬の内リンパ水腫軽減効果に関する検討2012

    • Author(s)
      江上直也、柿木章伸、坂本幸士、西岡利恵、竹田泰三、兵頭政光、山岨達也
    • Organizer
      日本耳鼻咽喉科学会総会・学術講演会
    • Place of Presentation
      新潟
    • Related Report
      2012 Research-status Report
  • [Presentation] メニエール病モデル動物におけるV2R拮抗的阻害薬の効果に関する検討2012

    • Author(s)
      江上直也、柿木章伸、竹田泰三、兵頭政光、山岨達也
    • Organizer
      日本めまい平衡医学会総会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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