• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Differentiation induction from embryonic stem cells to functional thyroid tissues

Research Project

Project/Area Number 24791762
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Otorhinolaryngology
Research InstitutionUniversity of Fukui

Principal Investigator

KANNO Masafumi  福井大学, 医学部附属病院, 医員 (90444215)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
KeywordsES細胞 / 甲状腺 / Lrh-1 / 胚性癌細胞 / 甲状腺濾胞上皮細胞 / 内胚葉 / F9細胞 / Lrh-1
Research Abstract

Differentiation induction from embryonic stem cells to thyroid tissues, which we is our objective, was accomplished by Dr. Antonica and others from Belgium in 2012, leading to transplantation into the body of a mouse and thus to recovery of thyroid function (Nature 491(7422):66-71.2012).
We inferred an important relation between this differentiation efficacy and the potency of embryonic stem cells to maintain the undifferentiated state. We analyzed it further to improve the differentiation induction efficacy of embryonic stem cells. Results demonstrated that the liver receptor homologue 1 (LRH1), which we specifically examined, was induced directly by Sox2 and Gabp. It played an important role in self renewal.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (1 results)

All 2014

All Journal Article (1 results) (of which Peer Reviewed: 1 results)

  • [Journal Article] Sex-determining region Y-box 2 and GA-binding proteins regulate the transcription of liver receptor homolog-1 in early embryonic cells.2014

    • Author(s)
      Kanno M, Yazawa T, Kawabe S, Imamichi Y, Usami Y, Ju Y, Matsumura T, Mizutani T, Fujieda S, Miyamoto K.
    • Journal Title

      Biochim Biophys Acta.

      Volume: 1839 Issue: 5 Pages: 406-14

    • DOI

      10.1016/j.bbagrm.2014.03.016

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi