Elucidation of cisplatin resistance mechanisms and a novel therapeutic target molecule in the head and neck cancer
| Project/Area Number |
24791790
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Oita University |
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Principal Investigator |
NOMI Nozomi 大分大学, 医学部, 助教 (40468020)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 頭頸部癌 / 化学療法 / 薬剤耐性 / 分子標的治療 |
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| Research Abstract |
Cisplatin is a key drug for head and neck cancer. However, acquired anticancer drug resistance is an obstacle to treatment. We have examined the relationship between cisplatin resistance mechanisms and expression of Lamin A/C in head and neck cancer. We established cisplatin-resistant cell lines in the three head and neck cancer. Lamin A/C was strongly expressed in resistant strains compared to the wild strain. We revealed the correlations between the sensitivity of cisplatin and carboplatin and the expression of Lamin A/C. We also showed relationship between the expression of actin and Lamin A/C expressions, which suggested that the expression of Lamin A/C might contribute the invasion and metastasis in head and neck cancer.
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Report
(3 results)
Research Products
(2 results)
