Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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Research Abstract |
Cisplatin is a key drug for head and neck cancer. However, acquired anticancer drug resistance is an obstacle to treatment. We have examined the relationship between cisplatin resistance mechanisms and expression of Lamin A/C in head and neck cancer. We established cisplatin-resistant cell lines in the three head and neck cancer. Lamin A/C was strongly expressed in resistant strains compared to the wild strain. We revealed the correlations between the sensitivity of cisplatin and carboplatin and the expression of Lamin A/C. We also showed relationship between the expression of actin and Lamin A/C expressions, which suggested that the expression of Lamin A/C might contribute the invasion and metastasis in head and neck cancer.
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