• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

The comprehensive profile analysis for regional metastatic potential of head and neck squamous cell carcinoma in vivo

Research Project

Project/Area Number 24791797
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Otorhinolaryngology
Research InstitutionYokohama City University

Principal Investigator

SANO Daisuke  横浜市立大学, 医学部, 助教 (10620990)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Keywords頭頸部癌 / 頸部リンパ節 / 同所性頭頸部癌モデル / 頸部リンパ節転移
Research Abstract

To identify the mechanism of regional metastasis of head and neck squamous cell carcinoma (HNSCC), we characterized regional metastatic potential in vivo using an orthotopic mouse model of HNSCC first. For further study, 15 HNSCC cell lines, establishing more than 80 % of tongue tumor formation in the model, were selected and whole gene microarray was performed. According to the result of principal component analysis based on all the probe sets utilized in our microarray analysis, 4 cells were selected for further analysis. Genes with an absolute fold change value > 1.5 were selected for further analysis.
The upstream and key nodes analysis with ExPlain® was then used to investigate upstream key molecules involved in the mechanisms of regional metastasis of HNSCC. The results showed molecules in AP-1 family with higher score suggesting that those molecules could be considered as key factors regulating the pathways related with regional metastasis of HNSCC.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (11 results)

All 2013 2012

All Journal Article (1 results) Presentation (10 results)

  • [Journal Article] 同所性頭頸部癌モデルを用いた頭頸部癌頸部リンパ節転移の機序の解明2013

    • Author(s)
      佐野大佑
    • Journal Title

      横浜医学

      Volume: 64(1) Pages: 21-26

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] The profile of regional and distant metastatic potential of head and neck squamous cell carcinoma in vivo2013

    • Author(s)
      Sano D, Hyakusoku H, Takahashi H, Oridate N
    • Organizer
      72nd Annual Meeting of the Japanese Cancer Association, Yokohama
    • Place of Presentation
      Japan
    • Related Report
      2013 Final Research Report
  • [Presentation] 頭頸部がん研究における経尾静脈移植による頭頸部癌肺転移モデルの有用性について2013

    • Author(s)
      百束紘, 高橋秀聡, 堀井千裕, 高橋優宏, 西村剛志, 田口享秀, 佐野大佑
    • Organizer
      第114回日本耳鼻咽喉科学会総会
    • Place of Presentation
      札幌
    • Related Report
      2013 Final Research Report
  • [Presentation] The profile of regional and distant metastatic potential of head and neck squamous cell carcinoma in vivo2013

    • Author(s)
      Daisuke Sano, Hiroshi Hyakusoku, Hideaki Takahashi, Nobhiko Oridate
    • Organizer
      72nd Annual Meeting of the Japanese Cancer Association
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 頭頸部癌研究における経尾静脈移植による頭頸部癌肺転移モデルの有用性についての検討2013

    • Author(s)
      百束 紘、高橋秀聡、堀井千裕、西村剛志、高橋優宏、田口享秀、佐野大佑
    • Organizer
      第114回日本耳鼻咽喉科学会・学術総会
    • Place of Presentation
      ロイトン札幌(北海道札幌市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] The regional metastatic potential of an orthotopic mouse model of head and neck squamous cell carcinoma2012

    • Author(s)
      Sano D, Takahashi H
    • Organizer
      71st Annual Meeting of the Japanese Cancer Association
    • Place of Presentation
      Sapporo, Japan
    • Related Report
      2013 Final Research Report
  • [Presentation] The applicability of murine orthotopic and experimental metastasis models for identifying the mechanisms of regional and distant metastasis of head and neck squamous cell carcinoma2012

    • Author(s)
      Sano D, Hyakusoku H, Takahashi H, Nishimura G, Takahashi M, Taguchi T, Matusda H, Myers JN
    • Organizer
      8th international conference on head and neck cancer
    • Place of Presentation
      Toronto, ON, Canada
    • Related Report
      2013 Final Research Report
  • [Presentation] 頭頸部がん研究における同所性頭頸部癌モデルの有用性について2012

    • Author(s)
      佐野大佑, 高橋秀聡, 百束紘, 堀井千裕, 高橋優宏, 西村剛志, 田口享秀, Jeffrey N. Myers
    • Organizer
      第113回日本耳鼻咽喉科学会総会
    • Place of Presentation
      新潟
    • Related Report
      2013 Final Research Report
  • [Presentation] 頭頸部がん研究における同所性頭頸部癌モデルの有用性について2012

    • Author(s)
      佐野大佑
    • Organizer
      第113回日本耳鼻咽喉科学会総会
    • Place of Presentation
      朱鷺メッセ(新潟県)
    • Related Report
      2012 Research-status Report
  • [Presentation] The applicability of murine orthotopic and experimental metastasis models for identifying the mechanisms of regional and distant metastasis of head and neck squamous cell carcinoma2012

    • Author(s)
      佐野大佑
    • Organizer
      8th international conference on head and neck cancer
    • Place of Presentation
      Metro Toronto Convention Centre(カナダ国トロント)
    • Related Report
      2012 Research-status Report
  • [Presentation] The regional metastatic potential of an orthotopic mouse model of head and neck squamous cell carcinoma2012

    • Author(s)
      佐野大佑
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      ロイトン札幌(北海道)
    • Related Report
      2012 Research-status Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi