Study for a new treatment for retinitis pigmentosa
| Project/Area Number |
24791850
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Ophthalmology
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| Research Institution | Kyoto University |
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Principal Investigator |
IKEDA Hanako 京都大学, 医学(系)研究科(研究院), 助教 (20372162)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 神経保護 / 網膜色素変性 |
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| Research Abstract |
We tried if VCP ATPase inhibitors would be a new treatment for retinitis pigmentosa. rd10, a model mouse for retinitis pigmentosa and rabbits having the mutated rhodopsin gene were used to try the neuroprotective effect of the inhibitors. In these animals, thickness of the retina was larger in the treated animals than in the non-treated ones. b-wave amplitudes of electroretinogram in the treated animals were larger than those in the non-treated animals. In rd12 mice, VCP ATPase inhibitors were administered after the age of 12 months, when the disease had progressed. In the elder rd12 mice, the thickness of the retina and the amplitudes of the b-wave were larger in the treated than in the non-treated mice. The newly synthesized VCP ATPase inhibitors would be a new neuroprotective treatment for retinitis pigmentosa.
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Report
(3 results)
Research Products
(38 results)
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[Journal Article] Imaging of localized retinal nerve fiber layer defects in preperimetric glaucoma using spectral-domain optical coherence tomography2014
Author(s)
Nukada, M., Hangai, M., Mori, S., Takayama, K., Nakano, N., Morooka, S., Ikeda, H. O., Akagi, T., Nonaka, A. & Yoshimura, N
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Journal Title
J Glaucoma
Volume: 23
Pages: 150-159
DOI
Related Report
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[Journal Article] High-Resolution Imaging of Retinal Nerve Fiber Bundles in Glaucoma Using Adaptive Optics Scanning Laser Ophthalmoscopy2013
Author(s)
Takayama K, Ooto S, Hangai M, Ueda-Arakawa N, Yoshida S, Akagi T, Ikeda HO, Nonaka A, Hanebuchi M, Inoue T, Yoshimura N
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Journal Title
Am J Ophthalmol.
Volume: 155(5)
Pages: 870-81
DOI
Related Report
Peer Reviewed
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[Journal Article] Macular Imaging in Highly Myopic Eyes With and Without Glaucoma2013
Author(s)
Nakano N, Hangai M, Noma H, Nukada M, Mori S, Morooka S, Takayama K, Kimura Y, Ikeda HO, Akagi T, Yoshimura N.
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Journal Title
Am J Ophthalmol
Volume: 155
Pages: 511-523
DOI
Related Report
Peer Reviewed
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[Journal Article] Wide 3-dimensional macular ganglion cell complex imaging with spectral-domain optical coherence tomography in glaucoma2012
Author(s)
Morooka, S., Hangai, M., Nukada, M., Nakano, N., Takayama, K., Kimura, Y., Akagi, T., Ikeda, H. O., Nonaka, A. & Yoshimura, N
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Journal Title
Invest Ophthalmol Vis Sci
Volume: 53
Pages: 4805-4812
DOI
Related Report
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[Journal Article] Retinal nerve fiber layer defects in highly myopic eyes with early glaucoma2012
Author(s)
Kimura, Y., Hangai, M., Morooka, S., Takayama, K., Nakano, N., Nukada, M., Ikeda, H. O., Akagi, T. & Yoshimura, N
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Journal Title
Invest Ophthalmol Vis Sci
Volume: 53
Pages: 6472-6478
DOI
Related Report
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