The effect of artificial vision for retina and optic nerve on brain and fellow eye.

• Project/Area Number: 24791853
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Ophthalmology
• Research Institution: Osaka University
• Principal Investigator: Nishida Kentaro 大阪大学, 医学(系)研究科(研究院), 助教 (70624229)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000); Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
• Keywords: 人工視覚 / 眼生理学 / 賦活化 / 電気刺激 / 脳神経

Outline of Final Research Achievements

We established the chronic electrical stimulation system and measuring system of evoked potentials in visual cortex for surprachoroidal transretinal stimulation and artificial vision by direct optic nerve electrical stimulation in rabbits and RCS rats. We could measure the electrical evoked potentials from 1 to 6 months after implantation. Some rats’ brain showed strong staining of GFAP after 6 month after implantation. Our result suggests the effect of optic nerve electrical stimulation on brain.

Research Products

• [Journal Article] Surgical feasibility and biocompatibility of wide-field dual-array suprachoroidal-transretinal stimulation prosthesis in middle-sized animals. (2016)
  • Author(s): LohmanTK, Kanda H, Morimoto T, Endo T, MiyoshiT, Nishida K, Kamei M, Walter P, Fujikado T
  • Journal Title: Graefes Arch Clin Exp Ophthalmol Volume: 254 Issue: 4 Pages: 661-673
  • DOI: 10.1007/s00417-015-3104-1
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Visual Sensation by Electrical Stimulation Using a New Direct Optic Nerve Electrode Device (2015)
  • Author(s): Nishida K, Sakaguchi H, Kamei M, Gonzalez C, Terasawa Y, Montoya R, Fujikado T, Fontan R, Ozawa M, Mercardo H, Nishida K
  • Journal Title: Brain Stimul. Volume: 8 Issue: 3 Pages: 678-681
  • DOI: 10.1016/j.brs.2015.03.001
  • Peer Reviewed
• [Presentation] Visual sensation by optic nerve electrical stimulation (2016)
  • Author(s): Nishida K
  • Organizer: Neurotalk2016
  • Place of Presentation: 北京（中華人民共和国）
  • Year and Date: 2016-05-20
  • Int'l Joint Research / Invited
• [Presentation] 人工視覚の現状と未来 (2015)
  • Author(s): 西田健太郎
  • Organizer: 第54回日本網膜硝子体学会総会・第32回日本眼循環学会 合同学会
  • Place of Presentation: 東京
  • Year and Date: 2015-12-04
• [Presentation] Visual Sensation by Electrical Stimulation Using a New Direct Optic Nerve Electrode Device (2015)
  • Author(s): Nishida K, Sakaguchi H, Kamei M, Cecilia-Gonzalez C, Terasawa V, Velez-Montoya R, Fujikado T, Sanchez-Fontan R, Ozawa M, Quiroz-Mercado H, Nishida K
  • Organizer: American Society of Retina Specialists 33rd Annual Meeting
  • Place of Presentation: ウィーン（オーストリア）
  • Year and Date: 2015-07-10
  • Int'l Joint Research
• [Presentation] Suprachoroidal Stimulation Approach to Visual Prosthetics (2015)
  • Author(s): Nishida K
  • Organizer: The 30th Asia-Pacific Academy of Ophthalmology Congress
  • Place of Presentation: 広州（中華人民共和国）
  • Year and Date: 2015-04-01
  • Int'l Joint Research / Invited
• [Presentation] Suprachoroidal Stimulation Approach to Visual Prosthetics (2015)
  • Author(s): Kentaro Nishida
  • Organizer: 30th Asia-Pacific Academy of Ophthalmology Congress
  • Place of Presentation: 広州（中華人民共和国）
  • Year and Date: 2015-03-31 – 2015-04-02
  • Invited
• [Presentation] The statue of retinal prosthesis (2014)
  • Author(s): Kentaro Nishida
  • Organizer: Asia-Pacific Academy of Ophthalmology Grand Rounds Around the World
  • Place of Presentation: 大阪
  • Year and Date: 2014-12-04
• [Presentation] The effect of electrical stimulation of optic nerve on rat brain (2014)
  • Author(s): Kentaro Nishida, Hirokazu Sakaguchi, Motohiro Kamei, Takashi Fujikado, Kohji Nishida
  • Organizer: Neuroscience 2014 Annual Meeting
  • Place of Presentation: ワシントン（アメリカ合衆国）
  • Year and Date: 2014-11-15 – 2014-11-22
• [Presentation] The effect of the locations of return electrodes on the electrical evoked potentials elicited by suprachoroidal-transretinal stimulation in rabbit eye. (2014)
  • Author(s): Kentaro Nishida, Hirokazu Sakaguchi, Takashi Fujikado, Motohiro Kamei, Kohji Nishida.
  • Organizer: 8th BIENNIAL WORLD RESEARCH CONGRESS
  • Place of Presentation: デトロイト（アメリカ合衆国）
  • Year and Date: 2014-09-27 – 2014-10-02
• [Presentation] Optimal electrode conditions for surprachoroidal-transretinal stimulation system to elicit electrically-evoked potentials (2013)
  • Author(s): Kentaro Nishida, Hirokazu Sakaguchi, Motohiro Kamei, Takashi Fujikado, Kohji Nishida
  • Organizer: Annual meeting of the Association for Research in Vision and Ophthalmology (ARVO)
  • Place of Presentation: Seattle, USA