Glaucoma and oxidative stress

Research Project

Project/Area Number	24791882
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Ophthalmology
Research Institution	University of Occupational and Environmental Health, Japan
Principal Investigator	MIYAMOTO Naoya 産業医科大学, 医学部, 助教 (30620570)
Project Period (FY)	2012-04-01 – 2015-03-31
Project Status	Completed (Fiscal Year 2014)
Budget Amount *help	¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000) Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000) Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000) Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords	緑内障 / 酸化ストレス / 線維柱帯細胞 / 緑内障点眼薬 / 分子生物学 / 転写 / 線維柱帯
Outline of Final Research Achievements	Glaucomatous TM cells highly express sirt1 when compared with normal TM cells. Tafluprost induces the expression of sirt1 through the activation of the c-mic transcription factor. TM cells showed reduced sensitivity to H2O2 when cells were treated with tafluprost. In addition, both transcription factor c-myc and sirt1 expression was enhanced by drug induced signal transduction through its receptor. These results indicate that tafluprost possesses a novel mechanism of action and function as potent protective agents against oxidative stress.

Report

(4 results)