Evaluation of the utility of growth factors for the treatment of hypertrophic scar

Research Project

Project/Area Number	24791919
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Plastic surgery
Research Institution	Kyorin University
Principal Investigator	ETO Hitomi 杏林大学, 医学部, 助教 (40612594)
Project Period (FY)	2012-04-01 – 2014-03-31
Project Status	Completed (Fiscal Year 2013)
Budget Amount *help	¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000) Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000) Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords	線維芽細胞 / 増殖因子 / 瘢痕治療
Research Abstract	To evaluate the utility of basic fibroblast growth factor (bFGF) for the treatment of hypertrophic scar, we investigated the effects on cultured fibroblasts of bFGF. On the basis of the findings that dermal fibroblast is mixed population consisted of some subpopulations having differing characteristics, superficial fibroblasts, which express anti-fibrotic factors, and deep fibroblasts, which express pro-fibrotic factors, were isolated and analysed by microarray and real-time PCR. Basic FGF were elucidated to increase the expression of specific factor for superficial fibroblasts, suggesting enhance the capability of the cells to suppress fibrosis.