Effect of differences in intraplatelet microRNA expression on platelet dysfunction after cardiopulmonary bypass
| Project/Area Number |
24791949
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Emergency medicine
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
MAEDA Sachiko 京都府立医科大学, 医学部附属病院, 病院助教 (90529512)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | 遺伝子治療 |
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| Research Abstract |
Thrombotic disorders by platelet dysfunction are frequently observed after cardiopulmonary bypass. We tested the hypothesis that differences in intraplatelet microRNA expression are related with intraplatelet Bax and platelet surface glycoprotein Ib expression, which subsequently affect perioperative blood loss.
In in vitro studies, we found that increase in intraplatelet miR-886-5p in thrombin-stimulated platelets has a strong relationship with preservation of platelet surface glycoprotein Ib expression and inhibition of intraplatelet Bax expression. In in vivo studies, we found a relationship between intraplatelet miR-886-5p expression, and platelet surface glycoprotein Ib and intraplatelet Bax expression in patients undergoing cardiac surgery after cardiopulmonary bypass. Patients showing increase in intraplatelet miR-886-5p expression had a tendency of decreased postoperative blood loss. Further studies are required to determine the complete clinical relevance of this relationship.
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Report
(3 results)
Research Products
(6 results)
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[Presentation] 敗血症性ショック症状がマスクされた膿胸合併神経芽細胞腫の一乳児例2012
Author(s)
駒井翔太, 徳平夏子, 志馬伸朗, 木村彰夫, 松山広樹, 黄瀬ひろみ, 澤田麻衣子, 橋本壮士, 加藤裕子, 井上美帆, 前田祥子, 坂東瑞樹, 嶋本早希, 橋本悟, 安炳文, 柳生茂希
Organizer
第57回日本集中治療医学会近畿地方会
Year and Date
2012-07-07
Related Report
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