Immune response after therapeutic brain hypothermia for severe brain injury
Project/Area Number |
24791955
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Emergency medicine
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Research Institution | Nippon Medical School |
Principal Investigator |
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Project Period (FY) |
2012-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
|
Keywords | 脳低温療法 / 重症脳損傷 / 心停止後症候群 / 免疫不全 / 免疫機能 / 中枢神経障害 / 脳卒中 / 頭部外傷 / 蘇生後脳症 |
Outline of Final Research Achievements |
We analyzed immune function of patients, who got severe brain injury due to post-cardiac arrest syndrome and received therapeutic brain hypothermia. Under the condition of 34 degrees Celsius, lymphocytes were decreased. Especially decrease of CD8 positive T cell was significant. After therapeutic brain hypothermia, the number of lymphocyte was normalized. But decrease of CD8 positive T cell was prolonged. Next we analyzed immune response with classification based on severity of brain injury. The patients with severe brain injury showed significant decrease of CD4 positive T cell. Though we could not observe significant difference of proportion of Th1 cell to Th2 cell, low Interleukin-4 (IL-4) and high Interleukin-10 (IL-10) were revealed in severely brain injured patients. IL-4 activates Th2 and IL-10 suppresses Th1, therefore both cellular immunitiy and humoral immunity were suppressed in spite of no difference of proportion of Th1 cell to Th2 cell.
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Report
(4 results)
Research Products
(6 results)