The expression analysis of the specific miRNA in the tumor endothelial cells

• Project/Area Number: 24791958
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Morphological basic dentistry
• Research Institution: Hokkaido University
• Principal Investigator: AKIYAMA Kosuke 北海道大学, 遺伝子病制御研究所, 客員研究員 (10609100)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 腫瘍血管新生 / 腫瘍血管内皮マーカー / miRNA / 血管新生阻害 / 腫瘍血管内皮細胞 / 血管新生阻害療法 / 血管新生阻害剤

Outline of Final Research Achievements

The anti-angiogenic therapy have been developed and used to inhibit the tumor growth and the metastasis. However, the currently used ant-angiogenic therapies have been reported to cause side effects because it is not specific for tumor blood vessels. In this study, endothelial cells were successfully isolated from mouse and human renal cell carcinoma tissues. Normal endothelial cells (NEC) and tumor edothelial cells (TEC) were analyzed with miRNA Micro Array, then some miRNAs ,which are expressed higher in TEC than in NEC, were identified. In addition, it is confirmed that miRNA-X is highly expressed in TEC compared to NEC with qRT-PCR analysis. In the future, we will analyze the miRNA-X function and develope the novel anti-angiogenic therapy.

Research Products

• [Journal Article] Inhibition of multidrug transporter in tumor endothelial cells enhances antiangiogenic effects of low-dose metronomic paclitaxel (2015)
  • Author(s): 1.Akiyama K., Maishi N., Ohga N., Hida Y., Ohba Y., Alam Mohammad Towfik, Kawamoto T., Ohmura H., Yamada K., Torii C., Shindoh M. and *Hida K.
  • Journal Title: Am J Pathol Volume: 185(2) Issue: 2 Pages: 572-580
  • DOI: 10.1016/j.ajpath.2014.10.017
  • Peer Reviewed / Open Access
• [Journal Article] Identification and expression of troponin T, a new marker on the surface of cultured tumor endothelial cells by aptamer ligand (2014)
  • Author(s): Ara MN., Hyodo M., Ohga N., Akiyama K., Hida K., Hida Y., Shinohara N., Harashima H
  • Journal Title: Cancer Med Volume: 3 Issue: 4 Pages: 825-834
  • DOI: 10.1002/cam4.260
  • Peer Reviewed / Open Access
• [Journal Article] Suprabasin as a novel tumor endothelial cell marker (2014)
  • Author(s): 3.Alam Mohammad Towfik，Nagao-Kitamoto H., Ohga N., Akiyama K., Maishi N., Kawamoto T., Shinohara N., Taketomi A., Shindoh M., Hida Y. and *Hida K
  • Journal Title: Cancer Sci Volume: 105(12) Issue: 12 Pages: 1533-1540
  • DOI: 10.1111/cas.12549
  • NAID: 120005539218
  • Peer Reviewed / Open Access
• [Journal Article] Identification of Tumor Endothelial Cells with High Aldehyde Dehydrogenase Activity and a Highly Angiogenic Phenotype (2014)
  • Author(s): 2.Ohmura-Kakutani H., Akiyama K., Maishi N., Ohga N., Hida Y., Kawamoto T., Iida J., Shindoh M., Tsuchiya K., Shinohara N., *Hida K
  • Journal Title: PLoS ONE Volume: 9(12) Issue: 12 Pages: e113910-e113910
  • DOI: 10.1371/journal.pone.0113910
  • NAID: 120005540289
  • Peer Reviewed / Open Access
• [Journal Article] Identification of Novel Targets for Antiangiogenic Therapy by Comparing the Gene Expressions of Tumor and Normal Endothelial Cells (2014)
  • Author(s): Otsubo T., Hida Y., Ohga N., Sato H., Kai T., Matsuki Y., Takasu H., Akiyama K., Maishi N., Kawamoto T., Shinohara N., Nonomura K., Hida K
  • Journal Title: Cancer Sci, Volume: in press
  • Peer Reviewed
• [Journal Article] Heterogeneity of tumor endothelial cells (2013)
  • Author(s): Hida K., Ohga N., Akiyama K., Maishi N., Hida Y.
  • Journal Title: Cancer Sci Volume: 104 Issue: 11 Pages: 1391-1395
  • DOI: 10.1111/cas.12251
  • Peer Reviewed
• [Journal Article] Tumor endothelial cells acquire drug resistance in a tumor microenvironment (2013)
  • Author(s): Hida K.
  • Journal Title: The Journal of Biochemistry Volume: 153 Issue: 3 Pages: 243-249
  • DOI: 10.1093/jb/mvs152
  • Peer Reviewed
• [Journal Article] Lysyl oxidase secreted by tumour endothelial cells Promotes angiogenesis and metastasiso (2013)
  • Author(s): Osawa T., et al., Ohga N., Akiyama K., Hida Y., Kitayama K., Kawamoto T, , Yamamoto K., Maishi N., Kondoh M., Onodera Y., Fujie M., Nonomura K., Shindoh M., Hida K.
  • Journal Title: Br. J. Cancer Volume: 109(8) Issue: 8 Pages: 2237-2247
  • DOI: 10.1038/bjc.2013.535
  • Peer Reviewed
• [Journal Article] Hypoxia-induced reactive oxygen species cause chromosomal abnormalities in endothelial cells in the tumor microenvironment (2013)
  • Author(s): Kondoh M., Ohga N., Akiyama K., Hida Y., Maishi N., Alam Mohammad Towfik, Inoue N., Shindoh M. and Hida K
  • Journal Title: PLoS ONE Volume: 8(11) Issue: 11 Pages: e80349-e80349
  • DOI: 10.1371/journal.pone.0080349
  • NAID: 120005367415
  • Peer Reviewed
• [Journal Article] The F-prostaglandin receptor is a novel marker for tumor endothelial cells in renal cell carcinoma (2013)
  • Author(s): Akiyama K., Ohga N., Maishi N., Hida Y., Kitayama K., Kawamoto T., Osawa T., Suzuki Y., Shinohara N., Nonomura K., Shindoh M., Hida K.
  • Journal Title: Pathol. Int. Volume: 63(1) Issue: 1 Pages: 37-44
  • DOI: 10.1111/pin.12031
  • Peer Reviewed
• [Journal Article] Tumor-Derived Microvesicles Induce Proangiogenic Phenotype in Endothelial Cells via Endocytosis (2012)
  • Author(s): T. Kawamoto, et al.
  • Journal Title: PLoS ONE Volume: 7 Issue: 3 Pages: e34045-e34045
  • DOI: 10.1371/journal.pone.0034045
  • Peer Reviewed
• [Journal Article] Biglycan is a aspecific marker and an autocrine angiogenic factor of tumour endothelial cells (2012)
  • Author(s): Yamamoto K, Ohga N, Hida Y, Maishi N, Kawamoto T, Kitayama K, Akiyama K, Osawa T, Kondoh M, Matsuda K, Onodera Y, Fujie M, Kaga K, Hirano S, Shinohara N, Shindoh M, Hida K.
  • Journal Title: Br J Cancer Volume: 106(6) Issue: 6 Pages: 1214-23
  • DOI: 10.1038/bjc.2012.59
  • Peer Reviewed
• [Journal Article] Prostacyclin receptor in tumor endothelial cells promotes angiogenesis in an autocrine manner (2012)
  • Author(s): Osawa T., Ohga N. , Hida Y., Kitayama K., Akiyama K., Onodera Y., Fujie M., Shinohara N., Nonomura K., Shindoh M. , Hida K
  • Journal Title: Cancer Science Volume: 103 Pages: 1038-1044
  • Peer Reviewed
• [Journal Article] CXCR7: A novel tumor endothelial marker in renal cell carcinoma (2012)
  • Author(s): Maishi N, Ohga N, Hida Y, Akiyama K, Shinohara N, Nonomura K, Shindoh M, Hida K. Kitayama K, Osawa T, Onodera Y
  • Journal Title: Pathol Int Volume: 65(5) Issue: 5 Pages: 309-17
  • DOI: 10.1111/j.1440-1827.2012.02792.x
  • NAID: 10031185206
  • Peer Reviewed
• [Journal Article] Heterogeneity of Tumor Endothelial Cells : Comparison between Tumor Endothelial Cells Isolated from Highly Metastatic and Low Metastatic (2012)
  • Author(s): Ohga N
  • Journal Title: Am J Pathol Volume: 180(3) Issue: 3 Pages: 1294-1307
  • DOI: 10.1016/j.ajpath.2011.11.035
  • Peer Reviewed
• [Journal Article] Tumor endothelial cells acquire drug resistance by MDR1 upregulation via VEGF signaling in tumor microenvironment (2012)
  • Author(s): Akiyama K.
  • Journal Title: Am J Pathol Volume: 180(3) Issue: 3 Pages: 1283-1293
  • DOI: 10.1016/j.ajpath.2011.11.029
  • Peer Reviewed
• [Presentation] 腫瘍血管内皮細胞のがん転移促進 (2014)
  • Author(s): 2.間石奈湖，大場雄介，秋山廣輔，大賀則孝，浜田淳一，山本和幸，川本泰輔，Alam Mohammad Towfik, 進藤正信，樋田泰浩，樋田京子
  • Organizer: 第1回六甲医学研究会
  • Place of Presentation: 六甲山ホテル（兵庫県神戸市）
  • Year and Date: 2014-11-07 – 2014-11-08
• [Presentation] 腫瘍内低酸素環境と腫瘍血管内皮の異常性の関連 (2014)
  • Author(s): 6.大賀則孝，近藤美也子，秋山廣輔，間石奈湖，北川善政，樋田泰浩，進藤正信，樋田京子
  • Organizer: 第73回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2014-09-25 – 2014-09-27
• [Presentation] CXCR7を標的とした新規血管新生阻害療法の可能性 (2014)
  • Author(s): 5.山田健司，間石奈湖，秋山廣輔，大賀則孝，川本泰輔，進藤正信，高橋典彦，神山俊哉，樋田泰浩，武冨紹信，樋田京子
  • Organizer: 第73回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2014-09-25 – 2014-09-27
• [Presentation] 腫瘍血管内皮細胞によるがん転移促進 (2014)
  • Author(s): 10.間石奈湖, 大場雄介, 秋山廣輔, 大賀則孝, 浜田淳一, 山本和幸, 川本泰輔,進藤正信, 樋田泰浩, 樋田京子
  • Organizer: 第79回日本インターフェロン・サイトカイン学会学術集会
  • Place of Presentation: 北海道大学（北海道札幌市）
  • Year and Date: 2014-06-19 – 2014-06-20
• [Presentation] 口腔扁平上皮癌における新規予後因子としてのVasohibin-1 (2014)
  • Author(s): 13.鳥居ちさほ，大賀則孝，秋山廣輔，間石奈湖，北條敬之,大廣洋一，小野貢伸,戸塚靖則，鄭 漢忠，樋田泰浩，進藤正信，佐藤靖史, 樋田京子
  • Organizer: 第103回日本病理学会総会
  • Place of Presentation: 広島国際会議場（広島県広島市）
  • Year and Date: 2014-04-24 – 2014-04-26
• [Presentation] 腫瘍血管内皮細胞のがん転移促進 (2014)
  • Author(s): 12.間石奈湖，大場雄介，大賀則孝, 秋山廣輔, 山本和幸，浜田淳一，川本泰輔，Alam Mohammad Towfik, 大村 瞳，進藤正信，樋田泰浩，樋田京子
  • Organizer: 第103回日本病理学会総会
  • Place of Presentation: 広島国際会議場（広島県広島市）
  • Year and Date: 2014-04-24 – 2014-04-26
• [Presentation] 腫瘍血管における新規血管新生関連因子Biglycan の発現と機能 (2014)
  • Author(s): 11.安永賢史，間石奈湖，秋山廣輔，山本和幸，Alam Mohammad Towfik，大賀則孝，篠原信雄，進藤正信，樋田泰浩，樋田京子
  • Organizer: 第103回日本病理学会総会
  • Place of Presentation: 広島国際会議場（広島県広島市）
  • Year and Date: 2014-04-24 – 2014-04-26
• [Presentation] Proangiogenic phenotype of Tumor Endothelial Cells induced by ROS accumulation (2014)
  • Author(s): 11.Hojo T., Maishi N., Akiyama K., Ohga N., Kondoh M., Shindoh M., Fujisawa T., Hida Y., Hida K
  • Organizer: The 18th International Vascular Biology Meeting
  • Place of Presentation: Miyakomesse(Kyoto, Japan)
  • Year and Date: 2014-04-17 – 2014-04-20
• [Presentation] Vasohibin-1 as a novel prognostic factor in oral squamous cell carcinoma (2014)
  • Author(s): Torii C., Ohga N., Akiyama K., Maishi N., Hojo T., Ohiro Y., Ono M., Totsuka Y., Kitagawa Y., Tei K., Hida Y., Shindoh M., Sato Y., Hida K
  • Organizer: The 18th International Vascular Biology Meeting
  • Place of Presentation: Miyakomesse(Kyoto, Japan)
  • Year and Date: 2014-04-14 – 2014-04-20
• [Presentation] P-gp inhibitor enhanced antiangiogenic activity in metronomic chemotherapy (2014)
  • Author(s): Akiyama K., Ohga N., Hida Y., Maishi N., Alam Mohammad Towfik, Kawamoto T., Omura H., Yamada Y., Torii C., Shindoh M., Ohba Y., Hida K.
  • Organizer: The 18th International Vascular Biology Meeting
  • Place of Presentation: Miyakomesse(Kyoto, Japan)
  • Year and Date: 2014-04-14 – 2014-04-17
• [Presentation] Tumor endothelial cells promote metastasis (2014)
  • Author(s): Maishi N., Ohba Y., Ohga N., Akiyama K., Hamada J., Yamamoto Y., Kawamoto T., Shindoh M., Hida Y., Hida K
  • Organizer: The 18th International Vascular Biology Meeting
  • Place of Presentation: Miyakomesse(Kyoto, Japan)
  • Year and Date: 2014-04-14 – 2014-04-17
• [Presentation] SBSN is a novel Tumor Endothelial Cell marker (2014)
  • Author(s): Alam Mohammad Towfik, Nagao H., Ohga N., Akiyama K., Maishi N., Kawamoto T., Shinohara N., Taketomi A., Shindoh M., Hida Y., Hida K
  • Organizer: The 18th International Vascular Biology Meeting
  • Place of Presentation: Miyakomesse(Kyoto, Japan)
  • Year and Date: 2014-04-14 – 2014-04-17
• [Presentation] CXCL12/CXCR7 axis is important for tumor endothelial cell angiogenic property (2014)
  • Author(s): Yamada K., Maishi N. Ohga N., Akiyama K., Kawamoto T., Alam Mohammad Towfik, Shindoh M. Takahashi N., Kamiyama T., Hida Y., Taketomi A., Hida K.
  • Organizer: The 18th International Vascular Biology Meeting
  • Place of Presentation: Miyakomesse(Kyoto, Japan)
  • Year and Date: 2014-04-14 – 2014-04-17
• [Presentation] 腫瘍血管内皮細胞を標的としたメトロノミックケモセラピーとP-gp阻害剤の併用療法の有効性の検討 (2013)
  • Author(s): 秋山廣輔，大賀則孝，樋田泰浩，間石奈湖，Alam Mohammad Towfik, 川本泰輔，大村 瞳，山田健司，鳥居ちさほ，進藤正信，大場雄介，樋田京子
  • Organizer: 第46回北海道病理談話会
  • Place of Presentation: 北海道大学医学部学友会館（札幌市）
• [Presentation] microvesiclesを介して腫瘍細胞由来のmiRNAが血管内皮細胞へ輸送される (2013)
  • Author(s): 川本泰輔，秋山廣輔，秋山廣輔，大賀則孝，間石奈湖，進藤正信，樋田泰浩，小坂展慶，落谷孝広，樋田京子
  • Organizer: 第72回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜（横浜市）
• [Presentation] P-gp阻害剤はメトロノミックケモセラピーの血管新生阻害効果を強める (2013)
  • Author(s): 秋山廣輔，大賀則孝，樋田泰浩，間石奈湖，Alam MohammadTowfik，川本泰輔，大村瞳，山田健司，鳥居ちさほ，進藤正信，大場雄介，樋田京子
  • Organizer: 第72回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜（横浜市）
• [Presentation] Tumor-derived miRNA is transported to endothelial cells by microvesicles (2013)
  • Author(s): 川本泰輔，秋山廣輔，大賀則孝，間石奈湖，進藤正信，樋田泰浩，小坂展慶，落谷孝広，樋田京子
  • Organizer: 第21回日本血管生物医学会学術集会
  • Place of Presentation: 千里阪急ホテル（大阪府豊中市）
• [Presentation] 腫瘍血管を標的としたMetronomic ChemotherapyとP-gp阻害剤の併用療法の有効性の検討 (2013)
  • Author(s): 秋山廣輔，大賀則孝，樋田泰浩，間石奈湖，Alam MohammadTowfik，川本泰輔，大村瞳，山田健司，鳥居ちさほ，進藤正信，大場雄介，樋田京子
  • Organizer: 第108回北海道癌談話会例会
  • Place of Presentation: 旭川グランドホテル（旭川市）
• [Presentation] Tumor-derived miRNA is transported to endothelial cells by microvesicles (2013)
  • Author(s): 川本泰輔，秋山廣輔，大賀則孝，間石奈湖，進藤正信，樋田泰浩，小坂展慶，落谷孝広，樋田京子
  • Organizer: 第108回北海道癌談話会例会
  • Place of Presentation: 旭川グランドホテル（旭川市）
• [Presentation] P-gp 阻害剤はパクリタキセルの抗腫瘍効果を増強する (2013)
  • Author(s): 秋山廣輔，大賀則孝，樋田泰浩，間石奈湖，Alam Mohammad Towfik，川本泰輔，大村 瞳，山田健司，鳥居ちさほ，進藤正信，樋田京子
  • Organizer: 第22回日本がん転移学会学術集会・総会
  • Place of Presentation: ホテルブエナビスタ（松本市）
• [Presentation] 腫瘍血管を標的としたMetronomic ChemotherapyとP-gp阻害剤の併用療法の有効性の検討 (2013)
  • Author(s): 秋山廣輔，大賀則孝，樋田泰浩，間石奈湖，Alam Mohammad Towfik, 川本泰輔，大村 瞳，山田健司，鳥居ちさほ，進藤正信，樋田京子
  • Organizer: 第102回日本病理学会総会
  • Place of Presentation: ロイトン札幌、さっぽろ芸文館（札幌市）
• [Presentation] ベラパミルはパクリタキセルの抗腫瘍効果を増強する (2013)
  • Author(s): 秋山廣輔，大賀則孝, 樋田泰浩，間石奈湖，Alam Mohammad Towfik, 川本泰輔，大村 瞳，山田健司，鳥居ちさほ，進藤正信，樋田京子
  • Organizer: 第67回日本口腔科学会学術集会
  • Place of Presentation: 栃木総合文化センター（宇都宮市）
• [Presentation] Tumor endothelium acquires drugresistance by MDR1/P-gp upregulationand metronomic chemotherapycombined with P-gp inhibitor enhancesantiangiogenic activity in vivo (2012)
  • Author(s): Akiyama K., Ohga N., Hida Y., Maishi N., Alam Mohammad Towfik., Kawamoto T., Omura H., Yamada K., Torii C., Sakamoto H. Matsuda A., Hida K
  • Organizer: The 20th annual Meeting of the Japanese Vascular Biology and MedicineOrganization, The 10th Korea-Japan Joint Symposium on Vascular Biology
  • Place of Presentation: あわぎんホール（徳島市）
• [Presentation] Characterization of stem-like tumor endothelial cells (2012)
  • Author(s): Hida K., Omura H., Akiyama K., Ohga N., Maishi N., Kawamoto T., Kondoh M., Hida Y.
  • Organizer: The 20th annual Meeting of the Japanese Vascular Biology and MedicineOrganization, The 10th Korea-Japan Joint Symposium on Vascular Biology
  • Place of Presentation: あわぎんホール（徳島市）
• [Presentation] Hypoxia induces angiogenic factors andaneuploidy in micirovascular endothelialcells (2012)
  • Author(s): Kondoh M., Ohga N., Akiyama K., Maishi N., Kawamoto T., Hida Y., Shindoh M., Hida K.
  • Organizer: The 20th annual Meeting of the Japanese Vascular Biology and MedicineOrganization, The 10th Korea-Japan Joint Symposium on Vascular Biology
  • Place of Presentation: あわぎんホール（徳島市）
• [Presentation] The role of Lysyl oxidase on proangiogenic phenotypes of tumor endothelial cells (2012)
  • Author(s): Akiyama K., Osawa T., Ohga N., Hida Y., Kitayama K., Kawamoto T., Yamamoto Y., Maishi N., Kondoh M., Shinohara N., Nonomura K., Shindoh M., Hida K
  • Organizer: The 71st Annual Meeting of the Japanese Cancer Association
  • Place of Presentation: ホテルさっぽろ芸文館（札幌市）
• [Presentation] Tumor-derived microvesicles induce proangiogenic phenotype in endothelial cells via endocytosis (2012)
  • Author(s): Kawamoto T., Ohga N., Akiyama K., Hirata N., Kitahara S., Maishi N., Osawa T., Yamamoto K., Kondoh M., Shindoh M., Hida Y., Hida K
  • Organizer: The 71st Annual Meeting of the Japanese Cancer Association
  • Place of Presentation: ホテルさっぽろ芸文館（札幌市）
• [Presentation] Biglycan is a specific marker and an autocrine angiogenic factor of tumour endothelial cells, (2012)
  • Author(s): Ohga N. ,Yamamoto K. , Hida Y., Akiyama K., Maishi N., Kawamoto T., Kitayama K., Osawa T., Hirano S, Shinohara N., Shindoh M
  • Organizer: The 71st Annual Meeting of the Japanese Cancer Association
  • Place of Presentation: ホテルさっぽろ芸文館（札幌市）
• [Presentation] The role of tumor endothelial cells in tumor metastasis (2012)
  • Author(s): Maishi N., Ohba Y., Ohga N., Akiyama K., Yamamoto Y., Hamada J., Kawamoto T., Osawa T., Kondoh M., Omura H., Shindoh M., Hida Y., Hida K
  • Organizer: The 71st Annual Meeting of the Japanese Cancer Association
  • Place of Presentation: ホテルさっぽろ芸文館（札幌市）
• [Presentation] Characterization of Aldehyde dehydrogenase(ALDH) positive tumor endothelial cells (2012)
  • Author(s): Omura H., Akiyama K., Ohga N., Maishi N., Hida Y., Kawamoto T., Kondoh M., Osawa T., Yamamoto Y., Iida J., Shindoh M., Hida K
  • Organizer: The 71st Annual Meeting of the Japanese Cancer Association
  • Place of Presentation: ホテルさっぽろ芸文館（札幌市）
• [Presentation] Biglycan is a specific marker and an autocrine angiogenic factor of tumor endothelial cells (2012)
  • Author(s): Yamamoto K., Ohga N., Hida Y., Maishi N., Kawamoto T., Kitayama K., Akiyama K., Osawa T., Kondoh M., Kaga K., Shinohara N., Shindoh M., Hirano S., Hida K.
  • Organizer: the 17th International Vascular Biology Meeting
  • Place of Presentation: Rein-Main-Hallen(Wiesbaden, Germany）
• [Presentation] Tumor endothelial cell s acquire drug resistance by MDR1 upregulation (2012)
  • Author(s): Hida K., Akiyama K., Ohga N., Hida Y., Kawamoto T., Sadamoto Y., Maishi N., Akino T., Kondoh M., Shindoh M
  • Organizer: the 17th International Vascular Biology Meeting
  • Place of Presentation: Rein-Main-Hallen(Wiesbaden, Germany）
• [Presentation] Tumor-derived microvesicles induce proangiogenic phenotype in endothelial cells via endocytosis (2012)
  • Author(s): Kawamoto T., Ohga N., Akiyama K., Hirata N., Kitahara S., Maishi N., Osawa T., Yamamoto K., Kondoh M., Shindoh M., Hida Y., Hida K
  • Organizer: the 17th International Vascular Biology Meeting
  • Place of Presentation: Rein-Main-Hallen(Wiesbaden, Germany)
• [Presentation] 腫瘍血管内皮細胞のプロスタサイクリン受容体は血管新生をオートクラインに促進する (2012)
  • Author(s): 土屋邦彦、大澤崇宏、大賀則孝、樋田泰浩、北山和子、秋山廣輔、小野寺雄一郎、篠原信雄、藤江学、進藤正信、野々村克也、樋田京子
  • Organizer: 第71回日本癌学会学術総会
  • Place of Presentation: ホテルさっぽろ芸文館（札幌市）
• [Presentation] 腫瘍血管内皮細胞のがん転移への関わり (2012)
  • Author(s): 間石奈湖、大場雄介、山本和幸、大賀則孝、浜田淳一、秋山廣輔、川本泰輔、大澤崇宏、近藤美弥子、大村瞳、樋田泰浩、樋田京子
  • Organizer: 第21回日本がん転移学会学術集会・総会
  • Place of Presentation: オリエンタルホテル広島（広島市）
• [Presentation] 腫瘍血管内皮細胞におけるALDHの発現解析とALDH高活性血管内皮細胞の特性解析 (2012)
  • Author(s): 大村瞳、大賀則孝、樋田泰浩、秋山廣輔、間石奈湖、近藤美弥子、大澤崇宏、山本和幸、川本泰輔、飯田順一郎、進藤正信、樋田京子
  • Organizer: 第21回日本がん転移学会学術集会・総会
  • Place of Presentation: オリエンタルホテル広島（広島市）
• [Presentation] Tumor-derived microvesicles induce proangiogenic phenotype in endothelial cells via endocytosis (2012)
  • Author(s): 川本泰輔、大賀則孝、秋山廣輔、間石奈湖、大澤崇宏、山本和幸、近藤美弥子、進藤正信、樋田泰浩、樋田京子
  • Organizer: 第28回日本DDS学会学術集会
  • Place of Presentation: 札幌コンベンションセンター（札幌市）
• [Presentation] 転移能の異なる腫瘍由来の血管内皮の特性解析 (2012)
  • Author(s): 大賀則孝、石川修平、樋田泰浩、秋山廣輔、間石奈湖、川本泰輔、進藤正信、樋田京子
  • Organizer: 第28回日本DDS学会学術集会
  • Place of Presentation: 札幌コンベンションセンター（札幌市）
• [Presentation] 腫瘍微小環境におけるVEGFシグナルを介したMDR1の発現亢進による血管内皮細胞の薬剤抵抗性獲得について (2012)
  • Author(s): 秋山廣輔、大賀則孝、樋田泰浩、川本泰輔、定本圭弘、石川修平、間石奈湖、秋野文臣、近藤美弥子、松田彩、井上農夫男、進藤正信、樋田京子
  • Organizer: 第66回日本口腔科学会学術集会
  • Place of Presentation: 広島国際会議場（広島市）
• [Presentation] 腫瘍微小 環境におけるVEGFシグナルを介したMDR1の発現亢進による血管内皮細胞の薬剤抵抗性獲得について (2012)
  • Author(s): 秋山廣輔、大賀則孝、樋田泰浩、川本泰輔、定本圭弘、石川修平、近藤美弥子、間石奈湖、大澤崇宏、山本和幸、進藤正信、樋田京子
  • Organizer: 第101回日本病理学会総会
  • Place of Presentation: 京王プラザホテル（東京都）