Analysis of bone healing process with the in vivo targeting system of NFkB decoy
| Project/Area Number |
24791959
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Tohoku University |
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Principal Investigator |
Nakamura Megumi 東北大学, 歯学研究科(研究院), 助教 (20431512)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 骨修復 / 炎症 / NF-κB / 規格化骨欠損 / 細胞 / 組織 / 再生医学 / ＮＦ－κＢ |
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| Outline of Final Research Achievements |
This study was designed to investigate bone healing process of the standardized calvarial defect in rats with downregulation of inflammation-related molecules by nuclear factor-kappa B (NFkB) decoy to elucidate the role of inflammation in bone repair. So far, we succeeded to establish the in vivo targeting system using type I collagen sponge as a carrier. In addition, we showed the mRNA expression of proinflammatory cytokines in developing bone of which bone formation process is comparable to that of healing bone.
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Report
(5 results)
Research Products
(3 results)
