Analysis of bone healing process with the in vivo targeting system of NFkB decoy

Research Project

Project/Area Number	24791959
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Morphological basic dentistry
Research Institution	Tohoku University
Principal Investigator	Nakamura Megumi 東北大学, 歯学研究科(研究院), 助教 (20431512)
Project Period (FY)	2012-04-01 – 2016-03-31
Project Status	Completed (Fiscal Year 2015)
Budget Amount *help	¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000) Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000) Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords	骨修復 / 炎症 / NF-κB / 規格化骨欠損 / 細胞 / 組織 / 再生医学 / ＮＦ－κＢ
Outline of Final Research Achievements	This study was designed to investigate bone healing process of the standardized calvarial defect in rats with downregulation of inflammation-related molecules by nuclear factor-kappa B (NFkB) decoy to elucidate the role of inflammation in bone repair. So far, we succeeded to establish the in vivo targeting system using type I collagen sponge as a carrier. In addition, we showed the mRNA expression of proinflammatory cytokines in developing bone of which bone formation process is comparable to that of healing bone.

Report

(5 results)