A novel preventive technique of dental diseases based on photo-dynamic anti-microbial therapy utilizing plaque discolinsg liquid
Project/Area Number |
24791977
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Functional basic dentistry
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Research Institution | Tohoku University |
Principal Investigator |
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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Keywords | 光線力学療法 / 殺菌 / 一重項酸素 / 水酸化ラジカル / プラーク染色剤 / ポリフェノール / レーザー |
Outline of Final Research Achievements |
Dyes contained in plaque disclosing liquid can be activated by photo-irradiation with a specific wavelength. The activated dyes generate singlet oxygen, a type of reactive oxygen species, when they return to the ground state. Since singlet oxygen has strong oxidative effect, it exerts bactericidal activity when reacts with bacteria. In the present study, it was demonstrated that the photodynamic antimicrobial therapy exerted strong bactericidal action on cariogenic bacteria (Streptococcus mutans). In addition, it was found that photo-irradiation of polyphenol aqueous solution also exerted bactericidal effect. Thus, it is suggested that this technique can be used a novel photodynamic antimicrobial therapy.
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Report
(4 results)
Research Products
(23 results)
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[Journal Article] Postantibiotic effect of disinfection treatment by photolysis of hydrogen peroxide.2014
Author(s)
Odashima, Y., Nakamura, K., Ikai, H., Kanno, T., Meirelles, L., Sasaki, K., Niwano, Y.
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Journal Title
Journal of Chemotherapy
Volume: 26(2):
Issue: 2
Pages: 92-100
DOI
Related Report
Peer Reviewed
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[Journal Article] Synergistic Effect of Proanthocyanidin on the Bactericidal Action of the Photolysis of H<SUB>2</SUB>O<SUB>2</SUB>2013
Author(s)
Ikai, H., Nakamura, K., Kanno, T., Shirato. M., Meirelles, L., Sasaki, K., Niwano, Y
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Journal Title
Biocontrol Science
Volume: 18
Issue: 3
Pages: 137-141
DOI
NAID
ISSN
1342-4815, 1884-0205
Related Report
Peer Reviewed
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[Journal Article] In vitro evaluation of the risk of inducing bacterial resistance to disinfection treatment with photolysis of hydrogen peroxide2013
Author(s)
Ikai, H., Odashima, Y., Kanno, T., Nakamura, K., Shirato, M., Sasaki, K., Niwano, Y
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Journal Title
PLoS ONE
Volume: 8(11)
Issue: 11
Pages: e81316-e81316
DOI
Related Report
Peer Reviewed
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[Presentation] 活性酸素2014
Author(s)
中村圭祐、菅野太郎、猪飼紘代、庭野吉己
Organizer
第41回日本防菌防黴学会年次大会
Place of Presentation
品川(東京)
Year and Date
2014-09-24 – 2014-09-25
Related Report
Invited
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[Presentation] Bactericidal action of photogenerated singlet oxygen from photosensitizers used in plaque disclosing agents2013
Author(s)
Ishiyama, K., Nakamura, K., Ikai, H., Kanno, T., Sasaki, K., Niwano, Y
Organizer
Innovative Research for Biosis-Abiosis Intelligent Interface Summer Seminar 2013
Place of Presentation
宮城
Related Report
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[Presentation] Advantages of new disinfection treatment utilizing photolysis of hydrogen peroxide - Low risk of inducing bacterial resistance and postantibiotic effect2013
Author(s)
Ikai, H., Odashima, Y., Nakamura, K., Shirato, M., Kanno, T., Sasaki, K., Niwano, Y
Organizer
Innovative Research for Biosis-Abiosis Intelligent Interface Summer Seminar 2013
Place of Presentation
宮城
Related Report
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