| Project/Area Number |
24791982
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Functional basic dentistry
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| Research Institution | Meikai University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 頭頸部扁平上皮癌 / がん幹細胞 / 分子標的薬 / Toll様受容体 |
|---|
| Research Abstract |
We determined whether CD44 positive cells of Head and Neck squamous cell carcinoma cell lines (HNSCC) have characteristics of Cancer Stem cells (CSCs). In the results, We confirmed that CD44 positive cells of HNSCC kept characteristics of CSCs.
These data suggested that the inhibition of CD44 expression in HNSCC may inhibit tumor recurrence and metastasis. Therefore, we studied the chemotherapeutic agent in existing that inhibits the expression of CD44 and induce apoptosis in the chemotherapeutic agent existing. As a result, combination therapy of gefitinib and irinotecan hydrochloride suppresses the expression of CD44, and we found that to induce HNSCC apoptosis.
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